| Sebringville Athletic Association Inc | Sebringville | $203K |
| Sechelt Congregation of Jehovah's Witnesses Sechelt British Columbia | Sechelt | $51K |
| Sechelt Groves Society | Sechelt | $17K |
| Sechelt Hospital Foundation Society | Sechelt | $2.5M |
| Sechelt Life Church | Sechelt | $152K |
| Sechelt Parish of the Anglican Church | Sechelt | $256K |
| Sechelt Public Library Association | Sechelt | $1.1M |
| Sechelt Seniors Activity Centre Society | Sechelt | $726K |
| Second Battalion the Royal New Brunswick Regiment (north Shore) Heritage Foundation Inc. | Bathurst | $5,169 |
| Second Blessings - Parkhill | Parkhill | $91K |
| Second Chance Animal Rescue of Windsor- Essex County | Windsor | $71K |
| Second Chance Animal Rescue Society | Athabasca | $3.3M |
| Second Chance Bible Church | Tilbury | — |
| Second Chance Car Museum Incorporated | Treherne | $357K |
| Second Chance Cheekye Ranch Society | Squamish | $198K |
| Second Chance Employment Counselling (wellington) Inc. | Guelph | $3M |
| Second Chance Kids | Owen Sound | $59K |
| Second Chance Ministries | Norwood | $6,930 |
| Second Chance Ministry | Tecumseh | $475K |
| Second Chance Pet Network | Dryden | $256K |
| Second Chance Scholarship Foundation Inc. | Toronto | $147K |
| Second Chance Wildlife Sanctuary | Pickering | $279K |
| Second Chipman United Baptist Church Inc. | Chipman | $121K |
| Second Church of Christ Scientist Vancouver B.C. | Vancouver | $1.1M |
| Second Falls United Baptist Church | Welshpool | $52K |
| Second Harvest Canada | Etobicoke | $382.9M |
| Second Kicks | Toronto | $3,782 |
| Second Mile Food Bank | Moncton | $332K |
| Second Mile Haiti Canada | Edmonton | $8,122 |
| Second North River Baptist Church Inc. | Second North River | $64K |
| Second Parents Transitional Home | Toronto | — |
| Second Peninsula Cemetery Association | Lunenburg | $18K |
| Second ST John's Lutheran Church | Sebringville | $80K |
| Second Stage Housing Association of Dartmouth | Dartmouth | $1.3M |
| Second Stage Housing Inc. | Saint John | $415K |
| Second Story Women's Centre | Lunenburg | $434K |
| Second Street Daycare Inc | Kirkland Lake | $1.5M |
| Second United Baptist Church | New Glasgow | — |
| SecondStreet.org | Regina | $1.2M |
| Secours-Amitie Inc | Lameque | $402K |
| Secours aux Ainés/elderaid | Outemont | $233K |
| Secours médical aux enfants | Lambton | $5,520 |
| Secours Missions | Saint Romuald | $103K |
| Secours Tiers-Monde Québec Inc. | Levis | $1.1M |
| Secret Santa | Unity | $10K |
| Secrétariat des évêques catholiques du Québec | Laval | $1M |
| Section 1 | North York | $34K |
| Securi-Coeur Maria-Chapdelaine | Dolbeau-Mistassini | — |
| Securi-Loge la Malbaie | La Malbaie | $477K |
| Sedalia Full Gospel Church | Sedalia | $6,700 |
| Sedalia Hall Club | Sedalia | — |
| Sedgewick & District Municipal Library | Sedgewick | $47K |
| Sedgewick Early Childhood Centre | Sedgewick | $173K |
| Sedgewick Historical Society | Sedgewick | $4,008 |
| Sedgewick Memorial Presbyterian Church | Tatamagouche | $61K |
| Sedgewick Senior Citizens Club | Sedgewick | — |
| Sedgewick Seventh-day Adventist Church | Lacombe | $171K |
| Sedgewick United Church | Sedgewick | $63K |
| Sedin Family Foundation | Victoria | $127K |
| Sedley Community Cultural Society | Sedley | $18K |
| Sedley New Horizons Centre | Sedley | $14K |
| Sedna Women's Shelter & Support Services Inc. | Oshawa | $2.5M |
| See-All Korean Canadian Community School | Toronto | — |
| See Change Initiative | Montreal-Ouest | $969K |
| See The Good Foundation | Kelowna | — |
| SEED Co-Creation | Toronto | — |
| Seed International Mission of Canada (Seed Canada) | Surrey | $291K |
| Seed of the Lamb Ministries Edmonton | Gibbons | $104K |
| Seed Programs Canada | Lombardy | $0 |
| Seed Sowers | Portage la Prairie | $56K |
| Seed Winnipeg Inc. | Winnipeg | $4.6M |
| SeedCare International Ministries | Vancouver | $281K |
| SeedChange Foundation | Ottawa | $742K |
| SeedChange / Sème l'avenir | Ottawa | $7.8M |
| Seedlings Foundation | Vancouver | $914K |
| SEEDS Connections | Calgary | $165K |
| Seeds Housing Inc. | Winnipeg | $1,000 |
| Seeds of Diversity Canada | Waterloo | $317K |
| Seeds of Hope 4 Autism | Scarborough | $27K |
| Seeds of Hope Childrens Ministry | Chilliwack | $2.4M |
| Seeds of Hope Evangelical Christian Ministry | Bancroft | $44K |
| Seeds of Hope Foundation | Toronto | $2.2M |
| Seeds of Leadership | Mount Hope | $261K |
| Seeds of Life Community Church | Altona | $234K |
| Seeds of Life Ministries | Brantford | $5,251 |
| Seeds of Love and Hope International Society | Maple Ridge | $593K |
| Seeds of Mercy Foundation Inc. | Crystal City | $66K |
| Seeds of Promise Support Services for Women International | Kitchener | $21K |
| Seeds Publications International | Mission | $57K |
| SEEDS (Set Apart Educate Empower Disciple Send) | Stayner | $3,000 |
| Seeds - Social Engagement Empowerment and Development Society | Edmonton | — |
| SEEDS - Supporting Every Eve's Daughter Safely | Cambridge | $393K |
| Seekers Christian Fellowship | Mississauga | $242K |
| SeekersGuidance Canada | Mississauga | $591K |
| SeekersHub Toronto | Milton | $13K |
| Seeley's Bay Pastoral Charge | Seeleys Bay | $162K |
| Seen Ministry | Sherwood Park | — |
| Seenso Institute for Public Health | Mont-Royal | $24K |
| Sef Foundation | North York | $6.6M |
| Segal Centre For Performing Arts | Montreal | $6M |
| Segue Career Options Inc. | Winkler | $599K |
| Seguin Pioneer United Church | Seguin | — |
| Seguin Pioneer United Church | Seguin | $46K |
| Seguin Township Public Library Board | Seguin | $358K |
| SehatCare Society | Calgary | $50K |
| Seicho-No-Ie Canada | Toronto | $153K |
| Seicho-No-Ie Canada Western Division | Vancouver | $30K |
| Seicho-No-Ie Humanity Enlightenment Movement (guelph) | Elmira | — |
| Seifried-Laciak Charitable Foundation | North York | $551K |
| Seigneurie mon toit | Causapscal | $696K |
| Seine Rat Roseau Watershed District | Steinbach | $1.2M |
| Seine River Christian Fellowship | Lorette | $101K |
| Seine River School Division | Lorette | $68.2M |
| Seismic Shift Arts Society | Vancouver | $1.6M |
| Seizan Buddhist Studies and Cultural Centre | Coquitlam | $40K |
| Seize Your Future / Ton avenir en main | Montreal | — |
| Seizure & Brain Injury Centre | Timmins | $392K |
| Séjour Marie Fitzbach | Chicoutimi | $572K |
| Séjour Santé Enfants Tchernobyl | Repentigny | $28K |
| Séjours Champêtres | Longueuil | $17K |
| Selah Charitable Trust | Toronto | $264K |
| Selah Fire | Drayton | $90K |
| Selah Treatment Centre | Woodstock | $34K |
| Selby Pastoral Charge of the United Church of Canada | Selby | $254K |
| Selcare International | Cambridge | $252K |
| Self Help and Recreation - Education P a Incorporation | Prince Albert | $1.4M |
| SelfDesign Learning Foundation | Vancouver | $24.8M |
| Selihom God's Church Calgary | Calgary | $155K |
| Selkirk Aboriginal Redemption Centre Church (church of God) Inc. | Selkirk | — |
| Selkirk and District Canadian Mental Health Association Incorporated | Selkirk | — |
| Selkirk and District Community Learning Centre Inc. | Pinawa | — |
| Selkirk and District Emergency Response System | Selkirk | $117K |
| Selkirk and Interlake Mental Health Support Centre Inc. | Selkirk | $564K |
| Selkirk Baptist Church | Selkirk | $91K |
| Selkirk Christian Chapel | Selkirk | $379K |
| Selkirk CHurch of Christ | Selkirk | $8,780 |
| Selkirk College Foundation | Castlegar | $1.3M |
| Selkirk Community Arts Centre Inc. | Selkirk | $93K |
| Selkirk Community Church Mennonite Brethren Inc. | ST Andrews | $449K |
| Selkirk Congregation of Jehovah's Witnesses Selkirk Manitoba | Selkirk | — |
| Selkirk Day CARE Inc. | Selkirk | $619K |
| Selkirk & District Community Foundation Inc. | Selkirk | $3.4M |
| Selkirk Food Bank Inc. | Selkirk | $125K |
| Selkirk Friendship Centre Inc. | Selkirk | $1.1M |
| Selkirk Gospel Chapel Inc. | Selkirk | $28K |
| Selkirk Nursery School Inc. | Selkirk | $177K |
| Selkirk Pastoral Charge | Selkirk | $285K |
| Selkirk Waterfront Development Corporation | Selkirk | $1,169 |
| Selm Academy | Newmarket | $2M |
| Selma Community Cemetery | Maitland | $8,968 |
| Selvayogam Foundation | Brampton | — |
| Semafo Foundation | Sainte-Therese | — |
| Semans Cemetery Association | Semans | $4,450 |
| Semans Drop-In Club Inc. | Semans | — |
| Semeurs De Charité/ Zoreah Tzedokos | Montreal | $229K |
| Semiahmoo Arts Society | Surrey | $692K |
| Semiahmoo Baptist Church | Surrey | $17K |
| Semiahmoo Community Safety Society | Surrey | $96K |
| Semiahmoo Congregation of Jehovah's Witnesses White Rock British Columbia | Surrey | $67K |
| Semiahmoo Family Place Association | Surrey | $97K |
| Semiahmoo House Society | Surrey | $19.5M |
| Semiahmoo Peninsula Marine Rescue Society | Surrey | $153K |
| Séminaire baptiste évangélique du québec (SEMBEQ) | Montreal | — |
| Seminaire de Chicoutimi | Chicoutimi | $443K |
| Séminaire de Chicoutimi - services éducatifs | Chicoutimi | $7.5M |
| Seminaire de Nicolet 2000 | Nicolet | $113K |
| Seminaire de Quebec | Quebec | $22.1M |
| Séminaire de Saint-Jérôme-Mont-Laurier | ST-Jerome | $431K |
| Seminaire de Sherbrooke | Sherbrooke | $23.9M |
| Séminaire du Sacré-Coeur | Grenville-Sur-La-Rouge | $5.5M |
| Séminaire Missionnaire Diocésain International Rédemptoris Mater De Québec | Quebec | $184K |
| Séminaire Saint-Francois | Saint-Augustin-De-Desmaures | $20.9M |
| Seminaire ST-Joseph de Trois-Rivieres | Trois Rivières | $2.1M |
| Seminary Loan Fund | Montreal | $428K |
| Seminary of Christ the King | Mission | $2.6M |
| Senaca Seniors Day Program Halton Inc | Oakville | — |
| Senaratne Charity Trust | Edmonton | $72K |
| Senator Hilliard McNab CM Memorial Foundation and Scholarship Fund Inc | Saskatoon | $2,222 |
| Senators Community Foundation | Kanata | $4.1M |
| Send 'em Off Smiling Children's Charity | Kitchener | $110K |
| Send International of Canada Inc. | Komoka | $3.7M |
| Sendero Centre Sexual Trauma Supports | Red Deer | $1.8M |
| Sending Sunshine | Mississauga | $28K |
| Seneca College of Applied Arts & Technology | North York | $618.1M |
| Senft Family Foundation | Vancouver | $624K |
| Seng Family Charitable Trust | North York | $393K |
| Sengmyung Saem Church of Canada | Vancouver | $12K |
| Senior Activities for Southwest Hamilton Inc. | Hamilton | $69 |
| Senior Animals in Need Today Society | Maple Ridge | $2.1M |
| Senior Chinese Society of Vancouver | Vancouver | — |
| Senior Citizens' Association of B.C. Branch #49 Powell River B.C. | Powell River | $121K |
| Senior Citizens Association of Peterborough | Peterborough | $413K |
| Senior Citizens Club of Fernie and District | Fernie | $134K |
| Senior Citizens Housing of South Surrey | Surrey | $837K |
| Senior Citizens Opportunity Neighbourhood Association S.c.o.n.a. | Edmonton | — |
| Senior Citizens Organization #33 of Carrot River Inc. | Carrot River | $22K |
| Senior Citizens Service Association of Saskatoon | Saskatoon | $7,998 |
| Senior Citizens' Society of Stony Plain | Stony Plain | $131K |
| Senior Citizens Special Services Society of West Vancouver | West Vancouver | — |
| Senior Citizens Sunshine Club of Vegreville | Vegreville | $100K |