| Southern Alberta Art Gallery Association | Lethbridge | $1.2M |
| Southern Alberta Bible Camp (1978) | Lethbridge | $4M |
| Southern Alberta Brain Injury Society | Calgary | $470K |
| Southern Alberta Community Living Association | Lethbridge | $12.6M |
| Southern Alberta Ethnic Association | Lethbridge | $429K |
| Southern Alberta Firearms Education Society | Lethbridge | $39K |
| Southern Alberta Heritage Language Association | Calgary | $237K |
| Southern Alberta Individualized Planning Association | Lethbridge | $209K |
| Southern Alberta Land Trust Society | Okotoks | $11.2M |
| Southern Alberta Myeloma Patient Society | Calgary | $154K |
| Southern Alberta Pioneers' Foundation | Calgary | $204K |
| Southern Alberta Rottweiler Rescue Society | Calgary | — |
| Southern Alberta Society for the Handicapped | Magrath | $8.6M |
| Southern Alberta Sports Equipment Bank Society | Calgary | $496K |
| Southern Alcare Society and Industries | Lethbridge | $1.4M |
| Southern Baptist Korean Association | Burnaby | $65K |
| Southern Chiefs' Organization Reconciliation Foundation Inc. | Headingley | $917K |
| Southern Connection Dog Rescue | Campbellville | $70K |
| Southern Cortes Community Association | Mansons Landing | $327K |
| Southern Frontenac Community Services Corporation | Sydenham | $2.6M |
| Southern Health | Southport | $479.1M |
| Southern Homes Society of Edmonton | Edmonton | — |
| Southern Interior Bluebird Trail Society | Vernon | $1,113 |
| Southern Interior Land Trust Society | Vernon | $215K |
| Southern Manitoba Concerts Inc. | Altona | $24K |
| Southern Manitoba Prophecy Conference Inc. | Winkler | $123K |
| Southern Okanagan Association for Integrated Community Living | Oliver | $4.5M |
| Southern Okanagan Secondary School Enrichment Fund Society | Oliver | $86K |
| Southern Ontario Baptist Association | Oakville | $58K |
| Southern Ontario Cocaine Anonymous | Toronto | $117K |
| Southern Ontario District of A.c.o.p. | Athens | $184K |
| Southern Ontario Locomotive Restoration Society | ST Jacobs | $1.6M |
| Southern Ontario Military Muster | Windsor | $7,094 |
| Southern Ontario Sheltie Rescue Society | Burlington | $34K |
| Southern Ontario Tres Dias | Petersburg | $155K |
| Southern Shores Church of God in Christ Mennonite Inc. | Leamington | $288K |
| Southern Stl'atl'imx Charitable Society | West Vancouver | — |
| Southern Vancouver Island Nature Trails Society | Victoria | $7,700 |
| Southern Vancouver Korean SDA Church | Abbotsford | $166K |
| Southern Victoria Cancer Assistance Fund | Rowena | — |
| Southern Victoria High School Trust Account | Perth-Andover | — |
| Southey Baptist Church | Southey | — |
| Southey Senior Citizens Club Inc. | Southey | $44K |
| Southey United Church | Southey | — |
| Southfield United Church | Southfield | $17K |
| Southfork Baptist Church | Leduc County | $118K |
| Southfraser Pregnancy Options Society | Surrey | $234K |
| Southgate Alliance Church | Edmonton | $421K |
| Southgate Baptist Church Edmonton | Edmonton | $309K |
| Southgate Christian Fellowship Society | Langley | $718K |
| Southgate Community Church | Kemptville | $1.5M |
| Southgate Congregation of Jehovah's Witnesses Lethbridge Alberta | Lethbridge | $34K |
| Southgate Presbyterian Church | Hamilton | $0 |
| Southhill Glen Foundation | Stouffville | $103K |
| Southlake Health | Newmarket | $593.2M |
| Southlake Health Foundation | Newmarket | $16M |
| Southlake Residential CARE Village | Newmarket | $26.3M |
| Southland Charitable Trust | Lethbridge | $5,861 |
| Southland Church Inc. | Steinbach | $5.8M |
| Southlands Farming and Food Foundation | New Westminster | $10K |
| Southlands Therapeutic Riding Society | Vancouver | $161K |
| Southlink Canada | Hamilton | $2,758 |
| Southman Gleaners Inc. | Schanzenfeld | $635K |
| Southminster Steinhauer United Church | Edmonton | $728K |
| Southminster United Church | Niagara Falls | $158K |
| Southminster United Church | Ottawa | $384K |
| Southquill Health Area Foodbank Inc. | Erickson | $109K |
| Southridge Community Church | ST Catharines | $4.3M |
| Southridge Community Church Lloydminster | Lloydminster | $477K |
| Southridge Congregation of Jehovah's Witnesses Medicine Hat Alberta | Medicine Hat | $36K |
| Southridge Fellowship Baptist Church | Langley | $2.8M |
| SouthShore Bible Church of Barrie | Barrie | $361K |
| Southshore Congregation of Jehovah's Witnesses Barrie Ontario | Barrie | $48K |
| Southside Baptist Church | Port Coquitlam | $227K |
| Southside Boularderie Volunteer Fire Department | Southside Boularderie | $86K |
| Southside Church of Christ | Lethbridge | $44K |
| Southside Community Church | Milton | $366K |
| Southside Community Church of the Nazarene | Edmonton | $433K |
| Southside Community Church | Surrey | $779K |
| Southside Pentecostal Assembly of Edmonton | Edmonton | $1.2M |
| Southside Victory Church Fellowship | Calgary | $2.9M |
| Southside Volunteer Fire Department Society | Southbank | $61K |
| Southside Worship Centre | Ajax | $616K |
| Southvan Foundation | New Westminster | $1.4M |
| Southview Alliance Church | Calgary | $3.5M |
| Southview Community Church | Medicine Hat | $227K |
| Southville Church of Christ | Weymouth | $41K |
| Southwest Alberta Regional Search And Rescue Society | Pincher Creek | $116K |
| Southwest Alberta Sustainable Community Initiative Centre | Pincher Creek | $262K |
| Southwest Area Refugee Mission Society | Calgary | $74K |
| Southwest Calgary Pavilion of Hope Church | Calgary | $120K |
| Southwest Coast SPCA Inc. | Stephenville | $193K |
| Southwest Community Baptist Church | Kamloops | $320K |
| Southwest Community Church of Edmonton | Edmonton | $471K |
| Southwest Community Options Inc. | Ninette | $2.7M |
| Southwest Cultural Development Group Inc. | Swift Current | $164K |
| Southwest Day CARE and Early Learning Centre Inc. | Moose Jaw | $755K |
| SouthWest Edmonton Seniors Association (SWESA) | Edmonton | $211K |
| Southwest Employment Services Society | Yarmouth | $1.7M |
| Southwest Facility Foundation Inc. | Swift Current | $205K |
| Southwest Hants Fire Society | Windsor | $47K |
| Southwest Homes Inc. | Swift Current | $5.3M |
| Southwest Horizon School Division | Melita | $28.4M |
| Southwest Interlake Pastoral Charge | Erksdale | $23K |
| Southwest Kitchener church of Christ | Kitchener | $43K |
| Southwest M.m.f. Early Learning Centre Inc. | Brandon | — |
| Southwest Middlesex Health Centre | Mount Brydges | $1.9M |
| Southwest Muslim Community Centre | Edmonton | $480K |
| Southwest Newcomer Welcome Centre Inc. | Swift Current | $1.2M |
| Southwest Nova Scotia Ostomy Chapter Affiliate of the United Ostomy Association Inc. | Hebron | $43K |
| Southwest Ontario Aboriginal Health Access Centre | Muncey | $26.7M |
| Southwest United Church | Lachine | $1,611 |
| Southwest Youth Emergency Shelter Inc. | Swift Current | $592K |
| Southwestern Manitoba Regional Library | Melita | $147K |
| Southwestern Ontario Fiddle and Step Dance Association | Stratford | $385 |
| Southwestern Ontario Gleaners Organization | Leamington | $646K |
| Southwestern Ontario Military Family Resource Centre | London | $697K |
| Southwestern Ontario Optimist Conductive Ed Trust Fund | Grande Pointe | $63K |
| Southwestern Ontario Suzuki Institute | Guelph | $213K |
| Southwestern Ontario Youth for Christ | Woodstock | $6.3M |
| Southwestern Saskatchewan Old Timers Museum Inc. | Maple Creek | $118K |
| Southwinds Baptist Church Calgary | Calgary | $386K |
| Southwold United Church Pastoral Charge | Shedden | $28K |
| Southwood Church of God | Calgary | $57K |
| Southwood United Church | Calgary | $268K |
| Soutien Autisme Soutien (S.AU.S.) | Candiac | $247K |
| Soutien aux Ainés/ Village Foundation - Helping Seniors | Dorval | — |
| Soutien aux familles réfugiées et immigrantes de l'Estrie (SAFRIE) | Sherbrooke | $412K |
| Soutien aux hommes agressé sexuellement durant l'enfance SHASE | Sherbrooke | $527K |
| Soutien Lactéa | Saint-Jean-Sur-Richelieu | $199K |
| Soutien O Sinistrés (SOS) | Montreal | — |
| Soutien technique international lien éducation-santé | Québec | $41K |
| Souvenirs et Mémoires de la Côte-des-Neiges | Montreal | $2,660 |
| Sou'West Nova Transit Association | Barrington | $425K |
| Sovereign Charitable Trust | Lethbridge | $53K |
| Sovereign Grace Baptish Church of London | London | $45K |
| Sovereign Grace Baptist Church | Mission | $98K |
| Sovereign Grace Baptist Church of Oromocto Inc. | Haneytown | $169K |
| Sovereign Grace Bible Church Inc. | Austin | $68K |
| Sovereign Grace Church Bradford | Bradford | $728K |
| Sovereign Grace Community Church | Sarnia | $283K |
| Sovereign Grace Family Church | Belleville | $16K |
| Sovereign Grace Fellowship | Port Hastings | $49K |
| Sovereign Grace Fellowship of Canada | Belleville | $61K |
| Sovereign Grace Reformed Church of Edmonton | ST. Albert | $76K |
| Sovereign House Christian Fellowship & Ministries | Waterford | — |
| Sovereign Hyland Cemetery Memorial Fund | Sovereign | $600 |
| Sovereign Order of ST. John of Jerusalem Knights Hospitaller | Vancouver | $125K |
| Sovereign Order of St. John of Jerusalem Knights Hospitaller Foundation (Okanagan Commandery) | Kelowna | — |
| Sovereign Order of St. John of Jerusalem Knights Hospitaller Foundation (Ontario Commandery) | Nepean | $7,650 |
| Sovereign Order of ST. John Victoria Commandery Foundation | Victoria | $801K |
| Sovereign Seeds | Burnaby | $224K |
| Sovereign Word Church | Beamsville | $917 |
| Sowers International | Ancaster | $324K |
| Sower's International Missionary Society | Surrey | — |
| Sowon Port Prayer Church | North York | $9,359 |
| Sozo Youth Ministeries | Brantford | — |
| SP Canada - Laurentides | Saint-Jerome | $408K |
| SP Canada - Laval | Laval | $293K |
| SP Canada - Montérégie | Saint-Lambert | $293K |
| SP Canada | Montreal | $3.6M |
| SP Canada - Montréal | Repentigny | $223K |
| SP Canada - Saguenay | Chicoutimi | $279K |
| SP Canada | Trois-Rivieres | $248K |
| SPA de Rivière-du-Loup | ST-Arsène | — |
| SPA Société protectrice des animaux des Cantons | Granby | $1.2M |
| Space Place Planetarium Canada (Toronto) | Toronto | $15K |
| Spadina Early Learning and Childcare Co-operative Limited | Saskatoon | $3M |
| Spafford Family Foundation | North York | $187K |
| Spalding Community Heritage Church Inc. | Spalding | $5,469 |
| Spalding New Horizons Senior Centre Inc | Spalding | $11K |
| Spallumcheen Pioneer Power Club | Vernon | $1,691 |
| Spanish Alliance Church | Surrey | $35K |
| Spanish America Outreach | Elmira | $20K |
| Spanish Baptist Church | Toronto | $214K |
| Spanish Christian Fellowship | Calgary | $43K |
| Spanish Church of God (7TH Day) | Pitt Meadows | — |
| Spanish Church of the Nazarene Truth and Life | London | — |
| Spanish Circuit 1A of Jehovah's Witnesses | Trois-Rivieres | — |
| Spanish Circuit 2A of Jehovah's Witnesses | Barrie | — |
| Spanish Circuit 2B of Jehovah's Witnesses | Hamilton | — |
| Spanish Circuit 3A of Jehovah's Witnesses | Edmonton | — |
| Spanish Circuit 3B of Jehovah's Witnesses | Langley | — |
| Spanish Circuit 4A of Jehovah's Witnesses | Hamilton | — |
| Spanish Circuit 4B of Jehovah's Witnesses | Brampton | — |
| Spanish Congregation of Jehovah's Witnesses Abbotsford British Columbia | Abbotsford | $14K |
| Spanish Congregation of Jehovah's Witnesses Barrie Ontario | Barrie | $20K |
| Spanish Congregation of Jehovah's Witnesses Brandon Manitoba | Brandon | — |
| Spanish Congregation of Jehovah's Witnesses Lethbridge Alberta | Coalhurst | $12K |
| Spanish Congregation of Jehovah's Witnesses Red Deer Alberta | Red Deer | — |
| Spanish Congregation of Jehovah's Witnesses Vaughan Ontario | Newmarket | — |
| Spanish Congregation of Jehovah's Witnesses Victoria British Columbia | Victoria | — |
| Spanish Congregation of Jehovah's Witnesses Whitby Ontario | Whitby | $22K |
| Spanish Congregation of Jehovah's Witnesses Winfield British Columbia | Vernon | $9,869 |
| Spanish Fellowship House of Prayer | Spanish | — |
| Spanish Indian Residential School Legacy Association | Massey | $3,655 |
| Spanish Pentecostal Church 'mount of Olives' | Brampton | $62K |
| Spanish Pentecostal Church of Calgary | Calgary | — |
| Spanish Pentecostal Church of Canada (Hamilton) | Calgary | $136K |
| Spanish Pentecostal Church of Montreal | Montreal-Nord | — |