| Shuswap Society for the Arts and Culture | Salmon Arm | — |
| Shuswap Theatre Society | Salmon Arm | $150K |
| Shuswap Trailrider Adaptive Adventure Society | Salmon Arm | — |
| Shuswap Victory Church | Sorrento | — |
| Shuswap Volunteer Search & Rescue Society | Salmon Arm | $215K |
| Shwachman Diamond Syndrome Canada | Mississauga | — |
| Shyan Der Buddhist Temple | Markham | $148K |
| SHYFT Youth Services Society | Yarmouth | $794K |
| Sibyllines | Montreal | $490K |
| Sicamous and District Seniors Centre Society | Sicamous | $75K |
| Sicamous Bible Church | Sicamous | $86K |
| Sicamous Community Church | Sicamous | — |
| Sicamous Preschool Society | Sicamous | — |
| Sicamous United Church & Pastoral Charge | Sicamous | $163K |
| Sick Muse Art Projects | Toronto | $231K |
| Sick Not Weak | Toronto | $44K |
| Sick + Twisted Theatre Inc. | Winnipeg | $201K |
| SickKids Centre for Community Mental Health | North York | $17.7M |
| SickKids Centre for Community Mental Health Learning Institute | Toronto | — |
| Sickkids Charitable Giving Fund | Toronto | $1.5M |
| Sickle Cell Association of BC | Vancouver | — |
| Sickle Cell Association of Ontario | Scarborough | $13K |
| Sickle Cell Awareness Group of Ontario Inc. | North York | $684K |
| Sickle Cell Disease Association of Canada/ Association d'anémie falciforme du Canada | Toronto | $19K |
| Sid Williams Theatre Society | Courtenay | $1.5M |
| Sida Bénévoles - Montréal | Montreal | $933K |
| Sidalys | Montreal | $1.7M |
| Siddha Yoga Dham Of Canada | Lachine | $50K |
| Siddhartha's Intent Society | Vancouver | $559K |
| Side by Side Foundation | North York | — |
| Sidebyside Children's Village Society | Vancouver | $1.7M |
| Sidh Shakti SH. Baba Balak Nath Bibi Satyadevi Satsang Bhavan | Etobicoke | $171K |
| Sidney Baptist Church | Stirling | $54K |
| Sidney Community Service Club Charitable Foundation | Belleville | — |
| Sidney Concert Society | Victoria | — |
| Sidney Lighthouse Church Inc. | Sidney | $27K |
| Sidney Museum and Archives Society | Sidney | $355K |
| Sidney Pre-School | Victoria | $79K |
| Sidoo Family Giving Foundation | Vancouver | $202K |
| Sids Calgary Society | Calgary | $113K |
| Siempre Juntos Mas Fuerte - Together We Are Stronger | Etobicoke | $100K |
| Sien Lok Society of Calgary | Calgary | — |
| Sierra Charitable Trust | Shaunavon | $5,003 |
| Sierra Club Canada Foundation | Ottawa | $1.5M |
| Sierra Club of British Columbia Foundation | Victoria | $3.1M |
| Sierra Leone Educational Partnership Inc. | Winnipeg | $835 |
| Sierra Leone Muslim Jamaat of Toronto | Brampton | $30K |
| Sierra Leone Refugee Resettlement Inc. | Winnipeg | — |
| Sierra Leone Sickle Cell Disease Foundation | Toronto | $4,957 |
| Sierra Leonean Community of British Columbia | Surrey | $106K |
| Sigis Child CARE Society | ST. Albert | $13.7M |
| Sigma Alpha Mu Foundation of Canada | Toronto | — |
| Sign Language Circuit 1A of Jehovah's Witnesses | Norval | — |
| Sign Language Circuit 1B of Jehovah's Witnesses | Trois-Rivieres | — |
| Sign Language Circuit 1C of Jehovah's Witnesses | Surrey | — |
| Sign Language Circuit CA-A7B of Jehovah's Witnesses | Surrey | — |
| Sign Language Congregation of Jehovah's Witnesses Calgary Alberta | Calgary | $4,338 |
| Sign Language Congregation of Jehovah's Witnesses Edmonton Alberta | Edmonton | $6,730 |
| Sign Language Congregation of Jehovah's Witnesses Halifax Nova Scotia | Halifax | — |
| Sign Language Congregation of Jehovah's Witnesses Hamilton Ontario | Wellandport | $13K |
| Sign Language Congregation of Jehovah's Witnesses Ottawa Ontario | Gloucester | $17K |
| Sign Language Congregation of Jehovah's Witnesses Vancouver British Columbia | Burnaby | $9,340 |
| Sign Language Congregation of Jehovah's Witnesses Victoria British Columbia | Vancouver | $1,925 |
| Sign Language Congregation of Jehovah's Witnesses Winnipeg Manitoba | Winnipeg | — |
| Sign Language East Congregation of Jehovah's Witnesses Toronto Ontario | Scarborough | $11K |
| Sign Language West Congregation of Jehovah's Witnesses Toronto Ontario | Brampton | $12K |
| Signal Hill Congregation of Jehovah's Witnesses Calgary Alberta | Calgary | $46K |
| Signal Hill Life Education Society | Langley | $393K |
| Signal Hill School Enhancement Society | Calgary | $84K |
| Signal Hill Tattoo Association Inc. | Goulds | $107K |
| Signature Support Services Society | Grande Prairie | $17.5M |
| Signet Centre Ministries of Lethbridge | Lethbridge | $92K |
| Signs Of Hope in Africa | Victoria | — |
| Signs Wonders and Miracles Ministry Inc. | Woodbridge | $24K |
| Sikh Association Brantford Ont | Brantford | $435K |
| Sikh Child Cultural Entertainment Society | Delta | $176K |
| Sikh Cultural Society | Kamloops | $335K |
| Sikh Cultural Society of Metropolitan Windsor | Windsor | $886K |
| Sikh Education & Research Centre of Windsor | Lasalle | — |
| Sikh Empowerment Visionary Association Inc. | London | $52K |
| Sikh Foundation of Canada Inc. | Toronto | $531K |
| Sikh Heritage Centre Limited | Brampton | $1.4M |
| Sikh Heritage Manitoba Inc. | Winnipeg | $14K |
| Sikh Heritage Museum of Canada | Mississauga | $136K |
| Sikh Human Development Foundation | Oakville | $26K |
| Sikh Lehar International Organization | Caledon | $118K |
| Sikh Missionary Association of Canada | Abbotsford | — |
| Sikh National Archives of Canada | Ottawa | $66K |
| Sikh Research Institute Canada | Vancouver | $580K |
| Sikh Sangat of Canada | Mono | $3.7M |
| Sikh Sewa International Society of Youth | Abbotsford | — |
| Sikh Sewa Society Toronto Inc. | Brampton | $62K |
| Sikh Society Calgary | Calgary | $828K |
| Sikh Society of Hamilton Wentworth | Hamilton | $2.2M |
| SIKH Society of Lethbridge Alberta | Lethbridge | $166K |
| Sikh Society of Manitoba Inc. | Winnipeg | $2.1M |
| Sikh Society of Niagara Falls (Ontario) | Niagara Falls | $498K |
| Sikh Society of Saskatchewan Inc. | Saskatoon | $766K |
| Sikh Society Regina Inc. | Regina | $925K |
| Sikh Spiritual Centre Toronto | Etobicoke | $2.9M |
| Sikh Virasat Incorporated | Brampton | $59K |
| Sikh Welfare Society | Oxford Mills | $0 |
| Sikhi Awareness Foundation | Surrey | $1.3M |
| Sikhi Maarag Trust Canada | Brampton | $79K |
| Sikhs for Humanity Foundation | Calgary | — |
| Sikhs Serving Canada Association | Mississauga | $2.2M |
| Sikka Foundation Inc. | Surrey | -$2.6M |
| Siksika Blackfoot Congregation of Jehovah's Witnesses Cluny AB | Strathmore | — |
| Siksika Health Services | Siksika | $13.5M |
| Silayan Filipino Community Centre | Toronto | $8,570 |
| Silence: Guelph's Portal for Adventurous New Sound Events | Guelph | $110K |
| Silence the Stigma | Edmonton | $10K |
| Silent Children's Mission | Schomberg | $373K |
| Silicz Foundation Inc. | Winnipeg | $196K |
| Siloam Development Foundation | Nobleford | $1.7M |
| Siloam Korean Evangelical Church | Toronto | $37K |
| Siloam Korean Methodist Church | Langley | $34K |
| Siloam Mission Inc. | Winnipeg | $20.5M |
| Siloam United Church of the Siloam Pastoral Charge | London | $639K |
| Siloam World Wide Ministries | Mississauga | $14K |
| Siloha Church | North York | $117K |
| Silstar Foundation | Toronto | $32K |
| Silton Community Club | Silton | — |
| Silton United Church | Silton | $4,756 |
| Silver Apple Foundation Inc. | North York | $72K |
| Silver Bay Bible Camp Inc. | Stonewall | $103K |
| Silver Birch Centre Bouleau d'Argent | Elliot Lake | $46K |
| Silver Creek Centre for Early Learning & Development | Etobicoke | $1.4M |
| Silver Creek Charitable Trust | Lethbridge | $264K |
| Silver Creek Spanish Congregation of Jehovah's Witnesses Brampton Ontario | Brampton | $28K |
| Silver Dollar Foundation/Fondation dollar d'argent | Laval | — |
| Silver Falls Congregation of Jehovah's Witnesses Thunder Bay Ontario | Thunder Bay | $69K |
| Silver Falls United Church | Quispamsis | — |
| Silver Family Charitable Foundation | Toronto | $2.6M |
| Silver Gummy | Calgary | $1.1M |
| Silver Harbour Seniors' Activity Centre Society | North Vancouver | $1.3M |
| Silver Heights Auxiliary Inc. | Raymore | $12K |
| Silver Heights Bible Church Inc. | Weyburn | $198K |
| Silver Heights Congregation of Jehovah's Witnesses Winnipeg Manitoba | Winnipeg | $222K |
| Silver Hills Institute | Abbotsford | — |
| Silver Lake Camp of the Wesleyan Methodist Church | Maberly | $1.2M |
| Silver Lake Forest Education Society | Kelowna | $567K |
| Silver Lake Mennonite Camp Inc. | Kitchener | $1.3M |
| Silver Ridge Bible Chapel | Alonsa | $62K |
| Silver Sage Agricultural Society | Brooks | $716K |
| Silver Sage Charitable Trust | Lethbridge | $29K |
| Silver Spire United Church | ST. Catharines | $885K |
| Silver Spring Charitable Trust | Lethbridge | $37K |
| Silver Springs Community Association | Calgary | $1.3M |
| Silver Star Adaptive Snow Sports | Vernon | $28K |
| Silver Star Congregation of Jehovah's Witnesses Vernon British Columbia | Vernon | — |
| Silver Star Society | Cambridge | — |
| Silver Stars Musical Revue Society | Calgary | $55K |
| Silver Threads Service Senior Citizens Activity Centre | Victoria | $781K |
| Silver Valley Charitable Trust | Lethbridge | — |
| Silver Valley Community Church | Maple Ridge | $134K |
| Silver Valley Gospel Chapel | Silver Valley | $67K |
| Silver Wings Access Van Inc. | Swift Current | $11K |
| Silvera for Seniors | Calgary | $41.4M |
| Silverado Congregation of Jehovah's Witnesses Calgary Alberta | Foothills | $53K |
| Silverhill Institute of Environmental Research and Conservation | Schomberg | $2,170 |
| Silverlines Philanthropy Corporation | Gloucester | — |
| Silvermere Congregation of Jehovah's Witnesses Mission British Columbia | Mission | $56K |
| Silverstone Spanish Congregation of Jehovah's Witnesses Etobicoke Ontario | North York | $37K |
| Silverthorn Congregation of Jehovah's Witnesses Olds Alberta | Olds | $30K |
| Silverthorn Symphonic Winds | Mississauga | $3,806 |
| Silverton United Church | Russell | $25K |
| Silverwinds Charitable Trust | Winnipeg | $238K |
| Silverwood Wildlife Rehabilitation Centre Inc. | Wapella | $44K |
| Sim Canada | Scarborough | $15M |
| Simaril Inc. | Winnipeg | $13.7M |
| Simbi Foundation | Vancouver | $18K |
| SimchaShare | North York | — |
| Simcoe and District Humane Society | Simcoe | $558K |
| Simcoe Congregation of Jehovah's Witnesses Simcoe Ontario | Port Dover | $375K |
| Simcoe County Christian High School Society | Barrie | $1.4M |
| Simcoe County Christian Senior Home Inc. | Barrie | $4.9M |
| Simcoe County District School Board (scdsb) | Midhurst | $880.6M |
| Simcoe County Historical Association | Barrie | $3,148 |
| Simcoe County Paramedic Association | Barrie | $22K |
| Simcoe County Regional Science Fair Committee | Barrie | $50K |
| Simcoe County YouthReach | Barrie | $253K |
| Simcoe Early Education and Development Services CO-Operative Inc. | Barrie | $4M |
| Simcoe Gospel Chapel Inc. | Simcoe | $141K |
| Simcoe Hall Settlement House | Oshawa | $862K |
| Simcoe Hall Settlement House Foundation | Oshawa | $41K |
| Simcoe Little Theatre | Simcoe | — |
| Simcoe Muskoka Child Youth and Family Services | Barrie | $55.9M |
| Simcoe Muskoka Workforce Development Board and Literacy Network | Barrie | $591K |
| Simcoe Park Iloko Congregation of Jehovah's Witnesses Vancouver British Columbia | Delta | $26K |
| Simcoe Peer Support for Mental Health and Addictions | Collingwood | $259K |
| Simcoe Presbytery Camp | Alliston | $243K |
| Simcoe Rotary Club Charitable Account | Simcoe | $104K |
| Simcoe Seniors' Centre | Simcoe | $81K |
| Simcoe Street United Church | Oshawa | $151K |
| Simcoe Youth Music Inc. | Oro-Medonte | $15 |
| Simcoside Bible Chapel | Orillia | $78K |
| Similkameen Baptist Church | Keremeos | $74K |
| Siminovitch Theatre Foundation | Toronto | $592K |
| Simmie Charitable Trust | Swift Current | $8,565 |