| School District of Mystery Lake 2355 | Thompson | $50.8M |
| School for Kids in Laos Inc. | Winnipeg | — |
| School Lunch Association Inc | St.john | $4.2M |
| School of Celtic Studies Inc. | Winnipeg | — |
| School of Dread Champions | Whitby | — |
| School of East Indian Languages and Performing Arts of Calgary | Calgary | $10 |
| School of Economic Science | Ottawa | $25 |
| School of Islamic Legacy Canada (SILC) Inc. | Mississauga | $14K |
| School of Islamic Studies Ontario | North York | $25K |
| School of Prayer Ministries | Kelowna | $32K |
| School of the Photographic Arts: Ottawa | Ottawa | $570K |
| School Orchards Africa Society | Cowichan Bay | $18K |
| School Sisters of Notre Dame of Ontario | Waterdown | — |
| School Sports Newfoundland and Labrador Inc. | ST John | $1.5M |
| School Time Charity Organization | Ajax | $314K |
| Schoolbox Inc. | Almonte | $108K |
| Schoolhouse Playcare Centre of Durham | Whitby | $24.2M |
| Schoolhouse Playcare Centre of Lakehead Inc. | Thunder Bay | $2.7M |
| Schoolkits 4 Success | Shelburne | — |
| Schools for the Children of the World.canada (scw.ca) | Toronto | $119K |
| Schools of Dreams Inc. | Hamilton | $51K |
| Schools Without Borders/ecoles Sans Frontieres | Loretto | $20K |
| Schroeder Ambulatory Centre | Richmond Hill | $11.1M |
| Schroeder Ambulatory Centre Foundation | Toronto | $92.7M |
| Schubert Centre Society | Vernon | $540K |
| Schuler Skating Club | Schuler | $11K |
| Schwartz / Reisman Centre | Toronto | $14.7M |
| SCI Canada Foundation | Lanark | — |
| Scic Foundation Inc. | Saint John | — |
| Science Atlantic | Bedford | $261K |
| Science Fair Foundation of British Columbia | Surrey | $482K |
| Science for Peace | Toronto | — |
| Science FUNdamentals Foundation of Alberta | Edmonton | $9,594 |
| Science Media Centre of Canada / Centre Canadien Sciences et Medias | Nepean | $39K |
| Science North-Science Nord | Sudbury | $27.7M |
| Science of Self Knowledge | Brampton | $144K |
| Science of Spirituality SKRM Inc | Brampton | $703K |
| Science of the Soul Study Centre Canada /centre d'Étude de la Science de l'Âme | East Garafraxa | $15 |
| Science on Stage Canada | Saint-Lazare | — |
| Science Rendezvous | Mississauga | $159K |
| Science Research 2.0 Canada | Toronto | $103K |
| Science Timmins Inc. | Timmins | $397K |
| Science To All Charitable Society | Nanaimo | $2,704 |
| Sciences@cecc | La Malbaie | $147K |
| Scientists in School | Pickering | $4.2M |
| Scleroderma Association of B.C. | North Vancouver | $269K |
| Scleroderma Association of Saskatchewan | Regina | $2,111 |
| Scleroderma Atlantic Society | Halifax | $74K |
| Scleroderma Canada | Hamilton | $364K |
| Scleroderma Manitoba Inc. | Oak Bluff | $22K |
| Scleroderma Society of Ontario | Hamilton | $340K |
| Sclerose en Plaques du Grand Charlevoix | Clermont | $17K |
| Sclérose en plaques Haute-Yamaska-Richelieu | Granby | $315K |
| Sclérose en Plaques ST-Hyacinthe - Acton | Saint-Hyacinthe | $274K |
| SCM de Gasperis Foundation | Woodbridge | $129K |
| Scope Society of Alberta | Calgary | $30.4M |
| Scotch Line Cemetery | Perth | $25K |
| Scotch Settlement Cemetery Company Ltd. | Scotch Settlement | $792 |
| Scotch Settlement Union Church | Scotch Lake | $60K |
| Scotdance Canada Association | Surrey | $97K |
| Scotdance New Brunswick Association Inc. | Oromocto | $30K |
| Scotia Chamber Players | Halifax | $987K |
| Scotia Festival of Music Foundation | Halifax | — |
| Scotia Pool Society | Truro | $448K |
| Scots of Canada | Scarborough | $6,055 |
| Scotsburn Fire Department | Scotsburn | $333K |
| Scotsburn Pastoral Charge | Scotsburn | $58K |
| Scotsburn Recreation Club | Scotsburn | $189K |
| Scott and Kim McCrea Foundation | Halifax | — |
| Scott-Bathgate LTD. Employees Charity Trust | Winnipeg | — |
| Scott Charitable Trust | Lethbridge | $42K |
| Scott Congregation of Jehovah's Witnesses Surrey British Columbia | Delta | $49K |
| Scott Dutton Family Foundation | Oakville | $70K |
| Scott Ecological Fund | Inverary | $16K |
| Scott F. Clarkson Education Fund | New Maryland | $95K |
| Scott Hindi Congregation of Jehovah's Witnesses Surrey British Columbia | Surrey | $12K |
| Scott Infant and Toddler Centre Inc. | Regina | $614K |
| Scott McIntyre Ministries | ST Catharines | $3,070 |
| Scott Mission | Toronto | $54.5M |
| Scott Street Mennonite Brethren Church | ST Catharines | $662K |
| Scott Young Ministries | Bowmanville | $1,250 |
| Scottish Heritage Association (miramichi) Inc. | Miramichi | $329K |
| Scottlea Gospel Chapel | ST Catharines | $159K |
| Scottlea Presbyterian Church | ST Catharines | $70K |
| Scoudouc River Trust | Montreal | $37K |
| Scout musulman | Montreal | $3,580 |
| Scout Properties (B.C./Yukon) | Vancouver | $715K |
| Scouting Waterloo Region | Waterloo | $18K |
| Scouts Canada | Ottawa | $33.1M |
| Scouts Canada-Cascadia Council | Ottawa | — |
| Scouts Canada Central Ontario | Toronto | — |
| Scouts Canada Chinook Region | Ottawa | — |
| Scouts Canada (Newfoundland and Labrador) Trust Foundation Inc. | ST. John's | $108K |
| Scouts Canada -Northern Lights Council | Ottawa | — |
| Scouts Canada Northern Ontario Council | Ottawa | — |
| Scouts Canada Nova Scotia Council | Dartmouth | — |
| Scouts Canada-Pacific Coast Council | Ottawa | — |
| Scouts Canada Provincial Council for Ontario | Oshawa | $336K |
| Scouts Canada Provincial Council for Prince Edward Is Land | Charlottetown | — |
| Scouts Canada Provincial Council of NFLD and Labrador | ST. John's | $23K |
| Scouts Canada Quebec Council | Ottawa | — |
| Scouts Canada-Saskatchewan Provincial Council | Ottawa | — |
| Scouts Canada - Tri-Shores Region | London | — |
| Scouts Canada Voyageur Council | Ottawa | — |
| Scouts Canada White Pine Council | North York | — |
| Scouts Francophones de la Colombie-Britannique | Coquitlam | $35K |
| Scouts Francophones de Maillardville | Coquitlam | $16K |
| Scouts Marins du Grand Montréal | Saint-Hubert | $213K |
| SCP Centennial Scholarship Fund Inc. | Regina | — |
| Screaming Weenie Productions | Vancouver | $300K |
| Screen Colons Canada | Toronto | — |
| Scribble Me Silly Art for Kids | Toronto | $6,334 |
| Scripture Gift Mission (canada) Inc. | Pickering | $243K |
| Scripture Union | Pickering | $767K |
| SCSBC Charitable Foundation | Langley | $13K |
| Scugog Council for the Arts | Port Perry | — |
| Scugog Lake Stewards Inc | Port Perry | $13K |
| Scugog Pastoral Charge | Port Perry | $41K |
| Sculptors' Society of British Columbia | Vancouver | $8,424 |
| Sculptor's Society of Canada | Toronto | $58K |
| Sculpture Art Academy | Vancouver | — |
| Scw'exmx Community Health Services Society | Merritt | $7M |
| Scw'exmx Parishes | Merritt | $8,026 |
| Scy Society for Children and Youth of B.C. | Vancouver | $2.5M |
| SD Lambton | Sarnia | $24K |
| SD43 Education Foundation | Coquitlam | $420K |
| SDC Foundation | Richmond | $529K |
| SDV Family Foundation | Montreal | $150K |
| Se Reconstruire Centre de santé du sein | Longueuil | $589K |
| Sea Island Heritage Society | Richmond | $5,055 |
| SEA Mission Inc. | Etobicoke | $174K |
| Sea Paws Rescue Ltd. | Burlington | $105K |
| Sea Shore Volunteer Fire Department | Bickerton West | $210K |
| Sea Smart School Society | Vancouver | $513K |
| Sea to Sea Foundation | Kanata | $24K |
| Sea to Sky Community Services Society | Squamish | $17.1M |
| Sea to Sky Crimestoppers | Squamish | $282 |
| Sea to Sky Faith and Culture Club | Squamish | $0 |
| Sea to Sky Forestry Centre Society | Squamish | $2,151 |
| Sea to Sky Hospice Society | Squamish | $276K |
| Sea to Sky Invasive Species Council | Whistler | $733K |
| Sea to Sky Student Bursary and Loan Association | Brackendale | $617 |
| Sea to Sky Thrivers Society | Whistler | $0 |
| Sea View Full Gospel Church Incorporated | Back Bay | $398K |
| Sea View Seniors Housing Society | Ucluelet | $383K |
| Seabird Island Education Society Lalme' Iwesawtexw | Agassiz | — |
| Seaboard Cemetery | Pictou County | $2,000 |
| Seachange Marine Conservation Society | Brentwood Bay | $1.9M |
| Seacliff Foundation | Vancouver | $1.2M |
| Seacliff Spanish Congregation of Jehovah's Witnesses Leamington Ontario | Wheatley | $16K |
| Seafair Mandarin Congregation of Jehovah's Witnesses Richmond British Columbia | Richmond | $18K |
| Seafarers Training Institute Institut de Formation des Mari NS | Montreal | $15K |
| Seaforth and District Food Bank | Seaforth | $109K |
| Seaforth CO-Operative Children's Centre Inc | Seaforth | $1.2M |
| Seaforth Community Hospital | Seaforth | $16.9M |
| Seaforth Community Hospital Foundation | Seaforth | $242K |
| Seager Wheeler Farm Historical Society Inc. | Rosthern | $54K |
| Seagrave United Church | Seagrave | $87K |
| Seal Cove Baptist Church | Grand Manan | $88K |
| Seal Harbour Cemeteries Association | Guysborough | $5,514 |
| Seal Harbour United Baptist Church | Goldboro | $5,768 |
| Seal with Hope Inc. | ST. John's | — |
| Sealegacy Canada Foundation | Qualicum Beach | $0 |
| Seamont Foundation-Fondation Seamont | Montreal | $4.5M |
| Sean McLeod Bursary Trust Fund | Parksville | — |
| Sean Ryan Children's Fund | Mississauga | $771 |
| SEAPC (Canada) | Markham | $1,100 |
| Search and Recovery Dog Association of Victoria | Victoria | $20K |
| Search and Rescue Dog Association of Canada | Airdrie | $3,284 |
| Search and Rescue Saskatchewan Association of Volunteers Inc | Porcupine Plain | $474K |
| Search and Rescue Society of British Columbia | Victoria | $180K |
| Search and Rescue Volunteer Association of Canada | Paradise | $2.5M |
| Search Recovery & Detection K9S of British Columbia Society Srdk9s of BC Society | Kamloops | $175K |
| Search & Rescue Dog Association of Alberta | Edmonton | $98K |
| Searchlight Service Dogs | Lisle | $80K |
| SEAS Foundation | Scarborough | $191K |
| Seaside Congregation of Jehovah's Witnesses Parksville British Columbia | Parksville | $40K |
| Seaside Recreation & Community Center Association | Brooklyn | $133K |
| Seaside Volunteer Sponsoring Committee Inc. | Old Shop | $74K |
| Seasons Centre | Barrie | $4.6M |
| Seasons Centre for Grieving Children | Barrie | — |
| Seasons Ministries Society | Saanichton | $142K |
| Seasons Trust | Uxbridge | $112K |
| Seastrom Scholarship of Life Pursuits | Calgary | — |
| Seaton Music Parents Association | Vernon | — |
| SEATS for Kids Coalition Corporation | Smiths Falls | $52K |
| Seaview Cemetery Company | Thomasville | — |
| Seaview Pentecostal Assembly | South Surrey | $672K |
| Seaway Congregation of Jehovah's Witnesses Cornwall Ontario | Cornwall | $55K |
| Seaway M.e./ FM Self Help Group | Cornwall | $5,172 |
| Seaway Park Congregation of Jehovah's Witnesses Sarnia Ontario | Sarnia | $105K |
| Seaway Senior Citizen's Club 1201 | Cornwall | $274K |
| Seaway Valley Community Health Centre Inc. | Cornwall | $5.1M |
| Seaway Valley Crime Stoppers | Long Sault | $64K |
| Seaway Valley Singers | Morrisburg | $17K |
| Seaway Valley Theatre Company/compagnie Theatrale Seaway Valley | Cornwall | $232K |
| Seaway Valley World Harvest Church | North York | — |
| Seba Beach Christian Fellowship | Seba Beach | $67K |
| Seba Beach Seniors Golden Age Club | Seba | $112K |
| Sebright Pastoral Charge | Sebright | — |