| Simmie Lutheran Bible Camp Association | Shaunavon | $36K |
| Simon Chang and Phyllis Levine Foundation | Montreal | — |
| Simon Chang Foundation For Change/Fondation Simon Chang Pour Le Changement | Montreal | $81K |
| Simon Fraser Hockey Scholarship Society | Langley | — |
| Simon Fraser University | Burnaby | $1B |
| Simon House Residence Society | Calgary | $3.6M |
| Simon Lake Stewardship | Naughton | $9,857 |
| Simonds Advent Christian Church | Simonds | $56K |
| Simonds High School Scholarship Fund Inc. | Saint John | $4,930 |
| Simonhouse Camp Inc. | Flin Flon | $561K |
| Simoniaques théatre | Montreal | $191K |
| Simpcw Tseptekwll and Research Society | Barriere | — |
| Simple Churches of The Christian and Missionary Alliance in Canada | North Vancouver | $194K |
| Simple Dreams Ministries Ontario Inc. | Stratford | $83K |
| Simple Plan Foundation | Montreal | $101K |
| Simply Compassion Advocacy Society | Airdrie | — |
| Simpson Community Development Society | Vancouver | — |
| Simpson-Markinch Charitable Foundation | Cardston | $84K |
| Simpson Masonic Lodge Scholarship Committee | Godfrey | $2,461 |
| Sims and Grace Kho Foundation | Victoria | $122K |
| Sinai Child CARE Services | North York | $538K |
| Sinai Health Foundation | Toronto | $97.4M |
| Sinai Health Giving Fund | Toronto | $0 |
| Sinai Health System | Toronto | $898.2M |
| Sinfonia Ancaster (2023) INC. | Ancaster | $105K |
| Sinfonia Mosaic | Coquitlam | $5,315 |
| Sinfonia Toronto | North York | $248K |
| Sing Canada Harmony Scholarship Fund | Guelph | $100K |
| Sing for Life Society of Alberta | Edmonton | $100K |
| Sing for Your Life Foundation | Kelowna | — |
| Sing! Prairies Society | Sherwood Park | $23K |
| Sing Tao (canada) Foundation | Markham | $2,033 |
| Sing! The Toronto Vocal Arts Festival | Toronto | $194K |
| Singh Sabha International Canada | Brampton | $13K |
| Singh Sabha Winnipeg Inc. | Winnipeg | $271K |
| Singin' Good News Society | Canoe | — |
| Singing Out | Toronto | $264K |
| Singing Waters Ministries | Mono | $3.1M |
| Singing with Parkinson's | North York | $19K |
| Single Mothers in Progress | North York | — |
| Single Mothers Inspiring Leadership in Education | Mulmur | $42K |
| Single Parent Association of Newfoundland | ST. John's | $827K |
| Single Women in Motherhood Training Program | London | $97K |
| Singyourjoy Young Adult Chorus Society | Victoria | $60K |
| Sinha Danse Inc | Montreal | $249K |
| Sino-Canada Cultural Association | Calgary | $102K |
| Sintaluta & District Community Club Inc. | Indian Head | — |
| Siobhan Richardson Foundation Inc | Winnipeg | $303K |
| Sionito Community Development Corporation | Toronto | $912K |
| Sioux-Hudson Literacy Council | Sioux Lookout | $2.2M |
| Sioux Lookout Food Bank | Sioux Lookout | $291K |
| Sioux Lookout Handi Transit | Sioux Lookout | — |
| Sioux Lookout Meno-Ya-Win Health Centre | Sioux Lookout | $73.6M |
| Sioux Lookout Meno-Ya-Win Health Centre Foundation | Sioux Lookout | $611K |
| Sioux Lookout Pastoral Charge | Sioux Lookout | $91K |
| Sipho | Mississauga | — |
| Sipiweske Museum Inc. | Wawanesa | $28K |
| Sir Alexander Mackenzie Historical Society | Peace River | — |
| Sir Frederic Fraser School Atlantic Provinces Resource Centre for the Visually Impaired | Halifax | $943K |
| Sir Frederick Banting Legacy Foundation | Alliston | $47K |
| Sir John a Macdonald Collegiate Institute Scholarship Fund Cstaff | Agincourt | — |
| Sir John Johnson Manor House Committee Inc | Williamstown | $47K |
| Sir Oliver Mowat Collegiate Institute | Scarborough | $8,475 |
| Sir Thomas Cropo Foundation Inc. | Gimli | $1.1M |
| Sir Wilfred Thomason Grenfell Historical Society | ST Anthony | $412K |
| Sir William Campbell Foundation | Toronto | $275K |
| Sir William F. Coaker Heritage Foundation Inc. | Port Union | $393K |
| Sir William Van Horne Elementary School Parent Advisory Council (School District No. 39) | Vancouver | — |
| Sir Winston Churchill Secondary School Alumni Association | ST. Catharines | $403 |
| Siri Guru Nanak Sikh Gurdwara of Alberta | Edmonton | $535K |
| Siri Guru Singh Sabha Cambridge | Cambridge | $1.3M |
| Sirie Limitless Community | Calgary | $9,781 |
| Sirimangalo International Buddhist Meditation Society Inc. | Kitchener | $82K |
| Sisem (daycare) Centre Society | Edmonton | $630K |
| Sisson Ridge United Baptist Church | Sisson Ridge | $124K |
| Sistars Community Economic Development CO-Op Inc. | Winnipeg | $1.1M |
| Sistema Huronia Music Academy | Midland | $21K |
| Sistema Toronto Academy | Toronto | $1.4M |
| Sister Ann Catherine Educational Society | Halifax | $1,933 |
| Sister Carmelina's Preschool Academy | Woodbridge | $157K |
| Sister Macnamara Preschool and Infant Daycare Inc | Winnipeg | $731K |
| Sister Triangle Inc | Regina | $22K |
| Sisterhood Ministries Canada Inc. | Grasswood | $236K |
| Sisterhood of Diman Foundation | Halifax | $69K |
| Sisterhood of Solel Congregation | Mississauga | $74K |
| Sistering-A Woman's Place | Toronto | $6.5M |
| Sisters of Charity - Caritas Retirement Centre | Halifax | $3.6M |
| Sisters of Charity Mount Saint Vincent | Halifax | $6.6M |
| Sisters of Charity of Ottawa | Ottawa | — |
| Sisters of Charity of Providence - Missions | Edmonton | — |
| Sisters of Charity of Providence of Calgary | Edmonton | $1.3M |
| Sisters of Charity of ST. Louis of Calgary | Calgary | — |
| Sisters of Charity of ST. Louis (sacred Heart Province | Calgary | — |
| Sisters of Charity of the Immaculate Conception | Saint John | — |
| Sisters of Divine Mercy Calgary | Calgary | $221K |
| Sisters of Holy Cross of ST. Joseph's Province | ST Andrews West | — |
| Sisters of Holy Cross Saint Theresa Province | Edmonton | — |
| Sisters of Life - Canada | Toronto | $645K |
| Sisters of Mission Service | Warman | — |
| Sisters of Our Lady of the Cross | Saskatoon | — |
| Sisters of Our Lady of the Missions Inc. | Winnipeg | $3.6M |
| Sisters of Our Lady Spouse of the Holy Spirit | Nepean | $27 |
| Sisters of Providence of ST. Vincent de Paul | Kingston | — |
| Sisters of Service of Canada | East York | $1.2M |
| Sisters of St. Joseph of Chambéry Corporation | Warman | $996K |
| Sisters of ST. Joseph (ukrainian) of Winnipeg Inc. | Winnipeg | $23K |
| Sisters of ST. Martha Prince Edward Island (motherhouse-Mount ST. Mary's) | Charlottetown | $2.3M |
| Sisters of the Addolorata Servants of Mary | Ottawa | — |
| Sisters of the Eucharistic Heart of Jesus of Canada | Halifax | $88K |
| Sisters of the Good Shepherd | Etobicoke | — |
| Sisters of the Good Shepherd Provincialate | Etobicoke | — |
| Sisters of the Immaculate Conception (canada) Inc | Putnam | — |
| Sisters of the Immaculate Heart of Mary Society | Coquitlam | $470K |
| Sisters of the Order of St. Benedict Inc. | Winnipeg | $1.8M |
| Sisters of the Sacred Heart of Ragusa | Welland | $328K |
| Sisters of the Sacred Heart of the Incarnate Word (ontario) | Woodbridge | $1.9M |
| Sisters Servants of Mary Immaculate (polish) of Alberta | Edmonton | $329K |
| Sisters Servants of Mary Immaculate Provincial Home | Toronto | $5.9M |
| Sisters Walking Together Society | Vancouver | $9,536 |
| Sistership Dragon Boat Association | Calgary | $119K |
| Sit-Mauricie (service d'Intégration au Travail) | Trois-Rivieres | $2.7M |
| Sit With Me Rescue | Ottawa | — |
| Site Historique du Banc-De-Paspebiac Inc. | Paspebiac | $677K |
| Site Historique Maritime de la Pointe-Au-Pere | Rimouski | $2.4M |
| Siudiac Air an Urlar Historical Cultural Society | Judique | $9,080 |
| Siva Vishnu Temple | Etobicoke | $162K |
| Sivananda Yoga Vedanta Centre | Val Morin | $1.3M |
| Sivananda Yoga Vedanta Centre (ontario) Inc | Brechin | $183K |
| Six Nations Community Food Bank | Ohsweken | $242K |
| Six Nations Health Foundation Inc. | Ohsweken | $53K |
| Six Nations Pentecostal Church | Ohsweken | $69K |
| Six Nations Polytechnic Inc. | Ohsweken | $19.4M |
| Six Words Foundation | Oakville | $420K |
| Sixteen island lake union church | Saint-Lambert | $1,847 |
| Sixteenth Avenue Gospel Chapel | Vancouver | $406K |
| Sixth Line Church | Stayner | $239K |
| SJHS Alumni Fund Incorporated | Saint John | $55K |
| Sjogren's Society of Canada/Societe de Sjogrens du Canada | Paris | $165K |
| SJS Saint John's School Society | Vancouver | $19.8M |
| SJSH - District du Canada | Saint-Hyacinthe | — |
| Ska:na Family Learning Centre | Windsor | $4.5M |
| Skagit Environmental Endowment Fund and Commission | Victoria | $1.9M |
| Skaha Lake Spanish Congregation of Jehovah's Witnesses Penticton British Columbia | Oliver | — |
| Skanderbeg Charitable Foundation | Vancouver | — |
| Skate for Kids | Toronto | — |
| SkateABLE | Kitchener | — |
| Skeels Danse | Montreal | $170K |
| Skeena Diversity Society | Terrace | $758K |
| Skeena Gursikh Society | Terrace | $50K |
| Skeena Knowledge Trust | Smithers | $206K |
| Skeena Valley Guru Nanak Brotherhood-Terrace BC | Terrace | $69K |
| SkeenaWild Conservation Trust | Terrace | $1.9M |
| Skeleton Lake Stewardship Association | ST. Albert | $36 |
| Skeleton Park Arts Festival | Kingston | — |
| Sketch Working Arts for Street Involved and Homeless Youth | Toronto | $2M |
| Ski for Light (canada) Inc. | Calgary | $106K |
| Ski Hawks Ottawa Inc. | Gloucester | $4,772 |
| Skidmore Foundation | Langley | $1.1M |
| Skilled Trades Fund | Thornhill | $195 |
| Skills Canada Alberta Association | Edmonton | $5.7M |
| Skills Canada - British Columbia Chapter | Vancouver | $1M |
| Skills Canada Manitoba Association Inc. | Winnipeg | $1.4M |
| Skills Canada-Newfoundland and Labrador Incorporated | Mount Pearl | $1.1M |
| Skills Canada Northwest Territories | Yellowknife | $531K |
| Skills Canada Nova Scotia Association | Dartmouth | $1.9M |
| Skills Canada-Ontario Competences Canada-Ontario | Waterloo | $7.9M |
| Skills Canada PEI Inc | Charlottetown | $276K |
| Skills Canada Saskatchewan Inc | Ottawa | $609K |
| Skills/compétences Canada Corporation | Ottawa | $12.8M |
| Skills for Change of Metro Toronto | Toronto | $9.8M |
| Skills For Hope Foundation | West Vancouver | $12K |
| Skills For Life Inc. | Brampton | $406K |
| SKILLS Society - Supporting the Citizenship of People with Disabilities | Edmonton | $24.7M |
| Skills Unlimited | Winnipeg | $474K |
| Skipping Stone Scholarship Foundation | Calgary | $1.7M |
| skirtsAfire Society | Edmonton | $526K |
| Skookum Jim Friendship Centre | Whitehorse | — |
| Skookumchuck Heritage Society | Egmont | $79K |
| Skudesnes Lutheran Church | Loreburn | $43K |
| Skudesness Lutheran Church | Camrose | $16K |
| Skwo:wech Parent Advisory Council | New Westminster | $48K |
| Sky Light Charitable Trust | Vulcan | $503 |
| Sky Woman Healing Society | Victoria | — |
| Skye Glen Cemetery Committee | Whycocomagh | $3,710 |
| Skye Mikko Foundation | Vancouver | — |
| SKYE (Science for Kitikmeot Youth and Educators) | Kugaaruk | — |
| Skyline Acres Baptist Church Inc. | Fredericton | $153K |
| Skyline Church | Richmond | — |
| Skyline Church Historical Society | Provost | $16K |
| Skyline Community Impact Foundation | Guelph | — |
| Sky's The Limit Foundation | Montreal | $2,539 |
| Sky's the Limit Youth Organization | Toronto | $58K |
| Skyview Alliance Church | Whitecourt | $182K |
| Skyview Charitable Trust | Portage la Prairie | $93K |
| Skyview Community Church of the Nazarene | Calgary | $606K |
| Skyway Chapel | Stoney Creek | $59K |
| Skyway Christian Assembly | Scarborough | $574K |
| Skyway Punjabi Congregation of Jehovah's Witnesses Hamilton Ontario | Hamilton | $12K |
| Skyway to Heaven Church Inc. | Miramichi | — |
| Slate River Baptist Church | Slate River | $135K |