| Sooke Region Communities Health Network Cooperative | Sooke | $459K |
| Sooke Region Historical Society | Sooke | $605K |
| Sooke Region Women's Cancer Support Society | Shirley | — |
| Sooke Rotary Community Organization | Sooke | $1,395 |
| Sooke Salmon Enhancement Society | Sooke | $65K |
| Sooke Senior Drop in Center | Sooke | — |
| Sooke Seniors Activity Society | Sooke | — |
| Sooke Shelter Society | Sooke | $1.8M |
| Sooke Transition House Society | Sooke | $885K |
| Soonats'ooneh Health Society | Prince George | — |
| Soonbokeum Little Church of Calgary | Calgary | $29K |
| Soong Ching Ling Children's Foundation of Canada | Vancouver | $62K |
| SOPAR-Bala Vikasa | Gatineau | $873K |
| Sophia Provident Fund Inc | Antigonish | — |
| Sophia Recovery Centre Inc. | Saint John | $1.7M |
| Sophia Smiles Pediatric Cancer Foundation | Lower Sackville | — |
| Sophie de Dieu de la Communauté Grecque des Authentiques Chrétiens Orthodoxes/Greek Community of Genuine Orthodox Christians God's Saint Sophia Church | Montreal | $98K |
| Sophie's Dog Adoption | Sorel-Tracy | $40K |
| Sop's Arm Pollards Point Volunteer Fire Department | Pollard's Point | $32K |
| Sorif Inc. | Montréal | $494K |
| Soroptimist Club of Toronto Trust | Toronto | $13K |
| Soroptimist Foundation of Canada | Waldheim | $584K |
| Soroptimist International of Cambridge Trust | Cambridge | $11K |
| Soroptimist International of Hamilton - Burlington | Burlington | — |
| Soroptimist International of Kawartha Lakes | Lindsay | $13K |
| Soroptimist International of Peterborough Trust | Peterborough | $64K |
| Soroptimist Nutrition Project | Saskatoon | $70K |
| Sorrento and Area Community Health Centre Society | Sorrento | $100K |
| Sorrento Centre Anglican Church of Canada | Sorrento | $1.2M |
| Sorrento Centre Foundation | Sorrento | — |
| Sorrento Community Hall Association | Sorrento | $28K |
| Sorrento & District Hospice Society | Sorrento | — |
| Sorrento Drop in Society Sorrento Oapo 165 | Sorrento | $17K |
| Sorrento Evangelical Free Church | Sorrento | $77K |
| Sorrento Food Bank | Sorrento | $123K |
| Sorties de rêve pour personnes hébergées inc. | Montreal | $87K |
| SOS Aînée Maltraitance | Montreal | $45K |
| SOS chats errants | Gatineau | $24K |
| SOS Children's Villages Canada / SOS Villages d'enfants Canada | Ottawa | $10.1M |
| SOS Grossesse Estrie | Sherbrooke | $678K |
| Sos Haiti - Sos Ayiti | Compton | $12K |
| Sos Handicapes | Varennes | — |
| Sos II Children's Village British Columbia (canada) Society | Vancouver | — |
| SOS Miss Dolittle | Saint-Henri-De-Levis | $434K |
| SOS Prairie Rescue Incorporated | Saskatoon | $435K |
| SOS Professionnels | Val-David | $183K |
| SOS Program Camrose (Service Options for Seniors) Society | Camrose | — |
| SOS Trees Coalition Inc. | Saskatoon | $9,651 |
| SOS Violence Conjugale | Montreal | $1.8M |
| SOSAKA Inc | Mont-Royal | $18K |
| SOSO World Ministries | Scarborough | $4.6M |
| Soteria Ministries Inc. | Grand-Sault/grand Falls | $22K |
| Soteriah International | Brampton | $15K |
| Souffle et Vie Sans Frontieres | Quebec | $5,597 |
| Soul Dancers | Port Hope | $28K |
| Soul Edge Ministries Inc. | Comox | $123K |
| Soul Harvest Christian Centre | Calgary | $7,391 |
| Soul Rescue Messianic Missionaries | Innisfil | — |
| Soul Sanctuary Church | Winnipeg | $1.5M |
| SoulJoy Foundation Inc. | Thunder Bay | $0 |
| Soulocentric performing arts society | Calgary | — |
| Soulpepper Theatre Company | Toronto | $7.2M |
| Souls' Anchor Foundation | Bedford | $182K |
| Souls for Christ Ministries | Toronto | — |
| Souls Friendly Ministry | Brampton | $7,000 |
| Soul's Harbour Inc | Centreville | $5,203 |
| Souls Harbour Rescue Mission | Halifax | $7.8M |
| Souls Harbour Rescue Mission Inc. | Regina | $3.7M |
| Soulstream Initiatives | Aldergrove | $292K |
| Sound of Faith Broadcasting | Kitchener | $955K |
| Sound of the Lord Foundation | Surrey | $31K |
| Sound of The Rockies Association | Calgary | $52K |
| Sound Servant Ministries | Oakville | $14K |
| Sound the Alarm: Music/theatre Society | New Westminster | $1.1M |
| Sound Times Support Services | Toronto | $2.6M |
| Sound Vision Canada (SVC) | Mississauga | $205K |
| Sounds of Hope Foundation | Vancouver | $156K |
| Sounds of the Next Generation | Cobourg | $182K |
| Soundstreams Canada Concerts/concerts Soundstreams du Canada | Toronto | $1.1M |
| Soundsunite Canada | Mississauga | — |
| Soup Sisters and Broth Brothers Society | Calgary | $171K |
| Soupe au bouton | Saint-Jean-Port-Joli | $509K |
| Soupe et Compagnie des Pays-d'en-Haut | ST-Sauveur | $304K |
| Soupe Populaire de Chez-Nous | Dolbeau | $53K |
| Soupe populaire de Hull inc. | Gatineau | $2.4M |
| Soupe Populaire Saint-François-de-Sales | Gatineau | $165K |
| Soupe pour elles | Montreal | — |
| Souper du partage Jean Pelchat | Magog | $257K |
| Souperjazz Inc. | Vanier | $10K |
| Soupière Kénogami (Sainte-Famille) | Jonquiere | $100K |
| Soup's On Inc. | Steinbach | $388K |
| Source Alimentaire Bonavignon | Maria | $418K |
| Source de Vie de St-Gabriel Inc. | Saint-Gabriel | $381K |
| Source d'Espoir Témis Inc. | Temiscouata-Sur-Le-Lac | $374K |
| Source Ministries Inc. | Rothesay | $72K |
| Source of Life Ministries International | Vanier | $36K |
| Source of Light Ministries Inc. | Hepburn | $32K |
| Source of Love and Hope Church | Drummondville | $32K |
| Sources Community Resources Foundation | Surrey | $2.3M |
| Sources Community Resources Society | Surrey | $33.1M |
| Sources of Knowledge Forum | Tobermory | $27K |
| Sources Vives Familles Monoparentales et Recomposees Inc. | Quebec | $192K |
| Sourire Sans Fin | Saint-Remi | $1.3M |
| Sourires Solidaires | Laval | $2.6M |
| Sourires Sucrés | Gatineau | $1,000 |
| Souris and District Heritage Club Inc. | Souris | $3,198 |
| Souris Congregate Meals Committee Inc. | Souris | $56K |
| Souris Cooperative Day CARE Centre Incorporated | Souris | $1M |
| Souris Food Bank | Souris | $102K |
| Souris Glenwood Foundation Inc. | Souris | $185K |
| Souris Gospel Chapel Inc. | Souris | $32K |
| Souris Group Home Association | Souris | $433K |
| Souris Health Auxiliary of the Assiniboine Regional Health Authority Inc. | Souris | $140K |
| Souris Health District Foundation Inc. | Souris | $158K |
| Souris Hillcrest Community Corporation Inc. | Souris | $64K |
| Souris-Moose Creek Wildlife Federation | Oxbow | $81K |
| Souris River Charitable Trust | Brandon | $154K |
| Souris River Watershed District | Reston | $1.8M |
| Souris Show Hall Foundation Ltd. | Souris | $160K |
| Souris Valley Antique Association | Midale | $32K |
| Souris Valley Christian Assembly Incorporated | Oxbow | $399K |
| Souris Valley Daycare Inc. | Oungre | $177K |
| Souris Valley Museum Inc. | Estevan | $203K |
| Souris Valley Theatre Inc. | Estevan | $263K |
| Sourp Nishan Armenian Apostolic Church of Cambridge | Cambridge | $195K |
| Sous le Toit de l'Échelon | Sainte-Adele | $483K |
| Sous le toit de P.A.L. | Montréal | $415K |
| South Abbotsford Mennonite Brethern Church | Abbotsford | $1.8M |
| South Alberta FASD Society | Lethbridge | $2.1M |
| South Alberta (japanese) Pastoral Charge | Lethbridge | $69K |
| South Alberta Service Dogs Foundation | Edmonton | $48K |
| South and Central Health Foundation | Grand Falls-Windsor | $700K |
| South and Metcalfe Non-Profit Housing Corporation | Simcoe | $524K |
| South Arm Community Association | Richmond | $2.2M |
| South Arm United Church | Richmond | $233K |
| South Asia Partnership - Canada/societe Asiatique des Partenaires - Canada | Ottawa | — |
| South Asia Rural Development Society | Vancouver | — |
| South Asian Autism Awareness Centre | Scarborough | $7.8M |
| South Asian Canadians Health & Social Services | Brampton | $304K |
| South Asian Centre of Windsor | Windsor | $183K |
| South Asian Church Edmonton | Edmonton | $37K |
| South Asian Humanitarian Aid and Resettlement Association (the Sahaara) | Edmonton | $0 |
| South Asian Long Term Care Foundation | Edmonton | — |
| South Asian Welcome Centre Inc. | Brampton | $28K |
| South Asian Women's and Immigrants' Services Inc. | Scarborough | $648K |
| South Asian Women's Centre | Toronto | $650K |
| South Bar and District Fire Department | South Bar | $235K |
| South Bay United Church | Milford | $64K |
| South Bend Charitable Trust | Lethbridge | $45K |
| South Branch Cemetery of South Branch in the County of Colchester | Bible Hill | $3,319 |
| South Brookfield Union Cemetery Inc. | Queens Co. | $465 |
| South Brookfield Zion United Baptist Church | South Brookfield | $18K |
| South Bruce Grey Health Centre | Walkerton | $61.4M |
| South Bruce Grey Health Centre (s.b.g.h.c.) | Kincardine | $82K |
| South Buxton Pastoral Charge | Merlin | $153K |
| South Calgary Chinese Evangelical Free Church | Calgary | $1.8M |
| South Calgary Community Church a Congregation of the North American Baptist General Conference | Calgary | $478K |
| South Caradoc United Church | Mount Brydges | $7,240 |
| South Cariboo Arts & Culture Society | 100 Mile House | $30K |
| South Cariboo Community Fellowship | 70 Mile House | $20K |
| South Cariboo Elizabeth Fry Society | Ashcroft | $612K |
| South Cariboo Health Foundation | 100 Mile House | $170K |
| South Cariboo Search & Rescue Society | 100 Mile House | $114K |
| South Cayuga Baptist Church | Dunnville | $64K |
| South Cayuga Community Church | Dunnville | $205K |
| South Central Cancer Resource Inc. | Morden | $407K |
| South Central Committee on Family Violence Inc. | Winkler | $1.4M |
| South Central Early Childhood Intervention Program Inc. | Moose Jaw | $245K |
| South Central Regional Library | Winkler | $1.4M |
| South Coast Special Needs Kids Inc. | Simcoe | — |
| South Coast Wellness Addictions and Mental Health | Simcoe | $6M |
| South Cochrane Addictions Services Inc. | Timmins | — |
| South Columbia Search and Rescue Society | Fruitvale | $85K |
| South Congregation of Jehovah's Witnesses Amherstburg Ontario | Amherstburg | $32K |
| South Congregation of Jehovah's Witnesses Powell River British Columbia | Powell River | $37K |
| South Congregation of Jehovah's Witnesses Stratford Ontario | Sebringville | $30K |
| South Cooking Lake United Church | Sherwood Park | — |
| South Country Assistance Inc. | Assiniboia | $1,164 |
| South Country Health CARE Foundation Inc | Assiniboia | $238K |
| South Cowichan Rotary Club Foundation | Shawnigan Lake | $5,781 |
| South Crosby Non Profit Housing Corporation | Elgin | $467K |
| South Cumberland Community CARE Centre Foundation | Parrsboro | $21K |
| South Delta Baptist Church | Delta | $1.5M |
| South Dumfries Non-Profit Housing Corporation | ST George | — |
| South Dundas Christmas Exchange | Morrisburg | $21K |
| South Dundas Lutheran Community Church | Williamsburg | $133K |
| South Durham United Church | South Durham | $12K |
| South East Adult Education | Moncton | $1.2M |
| South-East Asian Aid Fund (SEAAF) | Montreal | $62K |
| South East Chorus Inc. | Estevan | $4,584 |
| South East Cornerstone School Division No. 209 | Weyburn | $113.2M |
| South East Edmonton Seniors Association | Edmonton | $826K |
| South-East Grey Community Health Centre | Markdale | $6.9M |
| South-East Grey Support Services | Flesherton | $1.3M |
| South East Healthability Society Inc. | Moosomin | $302K |
| South East Helping Hands Inc. | Steinbach | $454K |
| South East Military Museum Incorporated | Estevan | $45K |
| South-East Ottawa Community Services | Ottawa | $36.2M |
| South East Rocky View Food Bank Society | Langdon | $92K |
| South East Whiteshell Cemetery Inc. | Whiteshell | $11K |