| Spanish Pentecostal Church The Good Shepherd | Victoriaville | $21K |
| Spanky Project | Picton | $8,584 |
| Spare Time Fun Centre | Vancouver | $469K |
| Spark Global Philanthropy Canada | West Vancouver | — |
| Spark Potential Canada | Bloomingdale | $215K |
| SPARK Society for Providing Animal Assisted Therapy in Kelowna | Kelowna | $162K |
| Sparks Humanitarian Society Canada | Vancouver | $288K |
| Sparks of Hope Charitable Organization | Scarborough | $1,200 |
| Sparling United Church | Rosser | $22K |
| Sparrow Baptist Church | Etobicoke | $82K |
| Sparrow Lake United Church Camp Inc. | Toronto | $1.1M |
| Sparrows Christian Housing Society | Smithers | $193K |
| Sparta and District Historical Society | Sparta | $37K |
| Sparta Community Society | Sparta | $11K |
| Spartan Foundation | Langley | $1.3M |
| Sparwood Christian Centre | Sparwood | $3,966 |
| Sparwood & District Arts and Heritage Council | Sparwood | $100 |
| Sparwood Food Bank | Sparwood | $360K |
| Sparwood Search & Rescue Society | Sparwood | $79K |
| Spay Day HRM Society | Halifax | $333K |
| Spay Neuter Initiatives Association | Oshawa | $57K |
| Spay Neuter Kingston Initiative | Kingston | $36K |
| SpayAid PEI Inc. | Stratford | — |
| SPCA Abitibi-Ouest | La Sarre | — |
| SPCA de la Montérégie (Société pour la prévention de la cruauté envers les animaux) | Ste-Angele de Monnoir | $1.2M |
| SPCA Lanaudière Basses-Laurentides (Société pour la prévention de la cruauté envers les animaux) | Saint-Calixte | $2.7M |
| SPCA - Peninsule Acadienne Inc. | Shippagan | $129K |
| SPCA St. John & District Branch Perpetual Trust | Toronto | $73K |
| SPCA Vancouver Hospital Trust Fund | Vancouver | -$83K |
| SPE Canadian Educational Foundation | Calgary | $104K |
| Speak Banana | Oakville | $3,400 |
| Speak Life Global | Hamilton | $289K |
| Speak Up for Paws | North Gower | $13K |
| Speak Up for Wildlife Foundation | Penticton | — |
| Speaking of Dogs Rescue Program | Etobicoke | $495K |
| Speaking Through C.R.A.I.G.-Solutions Inc. | Lake Lenore | $20K |
| Spearhead Huts Society | Whistler | $460K |
| Special Ability Riding Institute | Arva | $958K |
| Special Endowment Fund of I00f Senior Citizens Home Trust | Toronto | $52K |
| Special Equestrians Therapeutic Riding Association | Harrow | $74K |
| Special Hockey International | North York | $200 |
| Special Needs Adult Program Services Organization | Brampton | $868K |
| Special Olympics 2018 National Games Society | Antigonish | — |
| Special Olympics Alberta Association | Edmonton | $4.2M |
| Special Olympics British Columbia Society | Burnaby | $5.1M |
| Special Olympics Canada | Toronto | $18.3M |
| Special Olympics Manitoba Inc. | Winnipeg | $2.3M |
| Special Olympics Newfoundland and Labrador Inc. | ST. John's | $679K |
| Special Olympics Ontario Inc. | Toronto | $10.3M |
| Special Olympics Prince Edward Island Inc. | Charlottetown | $1.1M |
| Special Olympics Saskatchewan Inc. | Regina | $1.2M |
| Special Olympics Society of Nova Scotia | Halifax | $1.4M |
| Special Olympics Yukon Society | Whitehorse | $656K |
| Specialisterne Canada Inc. | Toronto | $792K |
| Spect-Arts Trois-Rivières | Trois-Rivières | — |
| Spectre de Rue Inc. | Montreal | $3.4M |
| Spectrum Artistic and Educational Media Association | Wiarton | — |
| Spectrum Core Community Services SCCS Inc. | Saskatoon | — |
| Spectrum Health Care Foundation | Toronto | $55K |
| Spectrum Intervention Group | Nepean | $1.5M |
| Spectrum Mothers Support Society | North Vancouver | $213K |
| Spectrum Satellite Clinic Inc | Brampton | — |
| Spectrum Society for Community Living | Vancouver | $15.1M |
| SPECTRUM Waterloo Region's Rainbow Community Space | Kitchener | $607K |
| Speech and Debate Canada Foundation | Toronto | $264K |
| Speech-Language & Audiology Canada (SAC) / Orthophonie et Audiologie Canada (OAC) | Ottawa | $3.4M |
| SpeechDojo Education Foundation | Edmonton | $1,715 |
| Speedside United Church | Rockwood | $73K |
| Speers Pioneer Memorial United Church | Speers | $49K |
| Spelling Bee of Canada | Toronto | $174K |
| Spence Family Foundation | Surrey | $344K |
| Spence Neighbourhood Association Inc. | Winnipeg | $3.6M |
| Spencer Home Foundation Inc. | Moncton | $22K |
| Spencer House Inc. | Markham | $17.8M |
| Spencer House Seniors Centre | Halifax | $805K |
| Spencercreo Finca Foundation | Coquitlam | — |
| SpencerCreo Foundation | Vancouver | $856K |
| Spencerville Agricultural Society | Spencerville | $650K |
| Spencerville MILL Foundation | Spencerville | $170K |
| Spencerville-Roebuck Pastoral Charge | Spencerville | $120K |
| Speroway | Burlington | $8.3M |
| SPES-Haiti | Sherbrooke | $19K |
| Spevakow Family Foundation Inc. | Vancouver | $641K |
| Sphère Santé Sexuelle Globale | Laval | $576K |
| Spina Bifida and Hydrocephalus Association of Canada | Winnipeg | $99K |
| Spina Bifida and Hydrocephalus Association of Manitoba | Morden | $11K |
| Spina Bifida and Hydrocephalus Association of Northern Alberta | Edmonton | $181K |
| Spina Bifida and Hydrocephalus Association of Nova Scotia | Bedford | — |
| Spina Bifida and Hydrocephalus Association of South Saskatchewan Inc. | Regina | — |
| Spina Bifida and Hydrocephalus Association of Southern Alberta | Calgary | $41K |
| Spina Bifida Families of Canada | Sussex | $48K |
| Spina Bifida & Hydrocephalus Association of P.e.i. | Charlottetown | $794 |
| Spinal Cord Injury Association Alberta | Edmonton | $2.2M |
| Spinal Cord Injury Canada | Toronto | $354K |
| Spinal Cord Injury Manitoba Inc. | Winnipeg | $1M |
| Spinal Cord Injury Newfoundland and Labrador Inc. | ST. John's | $534K |
| Spinal Cord Injury Ontario | Toronto | $7M |
| Spinal Cord Injury P.E.I. Inc. | Charlottetown | $177K |
| Spinal Cord Injury Saskatchewan Inc. | Saskatoon | $894K |
| Spinal Cord Injury Treatment Centre (northern Alberta) Society | Edmonton | $128K |
| Spinal Cord Society Canada | Quesnel | $8,098 |
| Spine Surgery Mission of Canada | Toronto | $28K |
| Spirit Abreast Dragon Boat Society | Chilliwack | $8,735 |
| Spirit Alive | Thunder Bay | $94K |
| Spirit Alive Outreach Ministry | Oshawa | $9,440 |
| Spirit Alive Pentecostal International | Toronto | $91K |
| Spirit and Life Bible Church | Etobicoke | $41K |
| Spirit Builders Program Inc. | Balcarres | — |
| Spirit Dance Centre for Spiritual Ecology Society | Sechelt | $1,611 |
| Spirit Hills | Eyebrow | $18K |
| Spirit Horse Centre Incorporated | Yellowhead County | $119K |
| Spirit North | Canmore | $5.5M |
| Spirit of Adriana Rajotte Society | Wainwright | $2,306 |
| Spirit of Christ Ministries | Honey Harbour | $11K |
| Spirit of Christ Ministries | Sorrento | — |
| Spirit of Formation Personal Development Society | Langley | $74K |
| Spirit of Grace Lutheran Church Brooks | Brooks | $53K |
| Spirit of Hope United Church | Edmonton | $473K |
| Spirit of Life a Community Organization | Richmond Hill | $23K |
| Spirit of Life Christian Centre Canada | Etobicoke | $128K |
| Spirit of Life Deliverance Ministry | North York | $21K |
| Spirit of Life Lutheran Church | Vancouver | $227K |
| Spirit of Peace United Church | Spirit River | — |
| Spirit of Pentecost | Mississauga | $334K |
| Spirit of Pentecost Charitable Property Corporation | Mississauga | $102K |
| Spirit of Praise Worship Centre | Brampton | $92K |
| Spirit of the Children Society | New Westminster | $6M |
| Spirit of the North Healthcare Foundation | Prince George | $4.8M |
| Spirit of Truth Church | Surrey | — |
| Spirit Renewal Ministries | Fredericton | $60K |
| Spirit River and District Agricultural Society | Spirit River | $277K |
| Spirit West United Church | Edmonton | $281K |
| Spiritans the Congregation of the Holy Ghost | Scarborough | $2.9M |
| SpiritEquip Ministries | Lasalle | $153K |
| Spirit's Mission Rescue Society | Gabriola | — |
| Spiritual Assembly of Baha'is of Lethbridge | Lethbridge | — |
| Spiritual Assembly of the Baha'is of Arnprior | Arnprior | — |
| Spiritual Assembly of the Baha'is of Campbell River | Campbell River | $26K |
| Spiritual Assembly of the Baha'is of Castlegar | Castlegar | $570 |
| Spiritual Assembly of the Baha'is of Centre Wellington | Fergus | $1,735 |
| Spiritual Assembly of the Baha'is of Charlottetown | Charlottetown | $71K |
| Spiritual Assembly of the Baha'is of Cochrane | Cochrane | $5,585 |
| Spiritual Assembly of the Baha'is of Coldstream | Coldstream | — |
| Spiritual Assembly of the Baha'is of Kelowna | Kelowna | $169K |
| Spiritual Assembly of the Baha'is of Mississippi Mills | Almonte | — |
| Spiritual Assembly of the Baha'is of Oakville | Oakville | $146K |
| Spiritual Assembly of the Baha'is of Pointe Claire | Pointe-Claire | — |
| Spiritual Assembly of the Baha'is of Red Deer | Red Deer | $59K |
| Spiritual Assembly of the Baha'is of Regina | Regina | $43K |
| Spiritual Assembly of the Baha'is of Rocky View County | Cochrane | — |
| Spiritual Assembly of the Baha'is of Saskatoon | Saskatoon | $57K |
| Spiritual Assembly of the Baha'is of Strathcona County | Sherwood Park | $39K |
| Spiritual Assembly of the Baha'is of Sunshine Coast Areas 'def' | Roberts Creek | — |
| Spiritual Assembly of the Baha'is of Victoria | Victoria | $181K |
| Spiritual Assembly of the Baha'is of Westmount | Westmount | — |
| Spiritual Assembly of the Baha'is of Whitehorse Yukon | Whitehorse | $57K |
| Spiritual Assembly of the Baha'is of Yellowknife | Yellowknife | $30K |
| Spiritual Awakening Foundation | Kamloops | $794 |
| Spiritual Blessing Lighthouse Ministries | London | $40K |
| Spiritual Community Church of the West | Heritage Pointe | $56K |
| Spiritual Counselling: Informed Through Sikhi | Brampton | $91K |
| Spiritual Emergence Service Society | Vancouver | — |
| Spiritual Growth Ministry | North York | $31K |
| Spiritual Heritage Education Network Inc | Waterloo | $29K |
| Spiritual Hospital | Ajax | $577K |
| Spiritual Leaders for the Next Generation | Toronto | $61K |
| Spiritual Motherhood of Priests (Ontario) Trust | Kanata | $36K |
| Spiritual Quest Wellness Society | Langley | — |
| Spiritual Rock Congregational Christian Church Inc. | ST John's | — |
| Spiritual Society Canada Inc. | Scarborough | $468K |
| Spiritualist Church of Canada | Orillia | $16K |
| Spiritualist Church of Divine Guidance Inc. | Winnipeg | $7,398 |
| Spiritualist Fellowship Church Incorporated | Winnipeg | $17K |
| Spiritualist Society of Barrie | Barrie | $11K |
| Spiritualist Society of Burlington | Burlington | $203K |
| Spiritus Chamber Choir and Performing Arts Ensemble Society | Calgary | $100K |
| Spiritus Ensemble Inc. | Kitchener | $42K |
| Spiritus Marching Arts Association | Calgary | $108K |
| Spiritus Vitae Catholic Health Sponsor | Edmonton | $2.8M |
| Spiritwind Christian Centre of Guelph | Guelph | $5.5M |
| SpiritWise Movement Ministries Inc. | Toronto | $19K |
| Spiritwood Health Complex Foundation Inc. | Spiritwood | $6,239 |
| Spiritwood Saskatchewan Congregation of Jehovah's Witnesses | Shell Lake | $11K |
| Spletzer Family Foundation Inc. | East ST Paul | $585K |
| Spoken Word Assembly (association) Edmonton | Edmonton | — |
| Spoken Word Ministries Association | Mission | $225K |
| Sponsoring Committee 902 (kiwanis) Squadron Summerland Acl of C | Summerland | $12K |
| Sponsoring Committee of No. 200 (Wolf) Squadron Royal Canadian Air Cadets | Sudbury | $9,960 |
| Sponsoring Committee of No. 242 (ross Ferguson) Squadron Royal Canadian Air Cadets | Markham | — |
| Sponsoring Committee of No. 999 Squadron Royal Canadian Ai R Cadets | Odessa | — |
| Sporobole | Sherbrooke | $1.7M |
| Sport by Ability Niagara Inc | ST. Catharines | — |
| Sport Central Association | Edmonton | $1.6M |
| Sport Ethics Scholarship Foundation | Ottawa | $34K |
| Sport For Calgary Foundation | Calgary | $529K |
| Sport Medicine Council of Alberta | Edmonton | $261K |
| Sport Plex Inc | Neguac | $134K |
| Sportaid International | Abbotsford | $2,600 |
| Sportedconnect Foundation | Calgary | $70K |
| Sports Fan Outreach | Hamilton | $0 |