| Sauble Beach Community Church Board of Management | Hepworth | $19K |
| Sauble Beach Precious Moments Childcare Centre | Sauble Beach | $1.2M |
| Sauble Christian Fellowship Church | Sauble Beach | $914K |
| Saugeen Academy | Durham | $208K |
| Saugeen Bach Choir | Sauble Beach | — |
| Saugeen Field Naturalists | Hanover | $4,347 |
| Saugeen Hospice Incorporated | Walkerton | $908K |
| Saugeen Memorial Hospital Auxiliary | Southampton | $50K |
| Saugeen Mobility and Regional Transit (S.M.A.R.T.) | Walkerton | $1.8M |
| Saugeen Pastoral Charge | Southampton | — |
| Saugeen Shores Community Church | Port Elgin | $317K |
| Saugeen Valley Children's Safety Village | Hanover | $74K |
| Saugeen Valley Conservation Authority | Formosa | $6.1M |
| Saugeen Valley Conservation Foundation | Formosa | — |
| Saul S. Abracen & Family Foundation | Lachine | — |
| Sault Accessible Sports Inc. | Sault Ste. Marie | — |
| Sault and District Evangelical Ministerium | Sault Ste. Marie | $101 |
| Sault Area Hospital | Sault Ste. Marie | $309.1M |
| Sault Area Hospitals Foundation | Sault Ste. Marie | $7.6M |
| Sault Community Health Centre | Sault Ste. Marie | $334K |
| Sault Finnish School - Soon Suomi Koulu | Sault Ste Marie | — |
| Sault North Rotary Charitable Trust | Sault Ste Marie | — |
| Sault North Waste Management Council | Sault Ste. Marie | — |
| Sault Search and Rescue Inc. | Sault Ste Marie | $158K |
| Sault Shrine Club Benevolent Trust Fund | Sault Ste Marie | $2,838 |
| Sault Ste Marie & 49TH Field Regiment R.c.a. Historical Society | Sault Ste Marie | $519K |
| Sault Ste. Marie Alcohol Recovery Home Inc. | Sault Ste Marie | $661K |
| Sault Ste Marie and District Finnish Canadian Historical Society (sault Ste Marie Ja Ympariston Kanadansuomalainen His | Prince Township | — |
| Sault Ste. Marie and District Group Health Association | Sault Ste Marie | $27.5M |
| Sault Ste. Marie and District Society for Prevention of Cruelty to Animals | Sault Ste Marie | $1.1M |
| Sault Ste. Marie Association for the Preservation of the Sault Ste. Marie Cross | Sault Ste-Marie | $8,272 |
| Sault Ste. Marie Church of the Nazarene | Mississauga | — |
| Sault Ste. Marie Down Syndrome Society | Sault Ste Marie | $25K |
| Sault Ste. Marie Helping Hands | Sault Ste. Marie | $42K |
| Sault Ste. Marie Insectarium | Sault Ste. Marie | $199K |
| Sault Ste. Marie Public Library | Sault Ste Marie | $3.8M |
| Sault Ste. Marie Region Conservation Authority | Sault Ste Marie | $866K |
| Sault Ste. Marie Riverside Congregation of Jehovah's Witnesses Inc. | Sault Ste. Marie | $52K |
| Sault Ste. Marie Rotary Club Charitable Trust | Sault Ste. Marie | $588K |
| Sault Ste. Marie Soup Kitchen Community Centre | Sault Ste Marie | $660K |
| Sault Ste Marie Symphony Association | Sault Ste. Marie | $176K |
| Sault Ste Marie Zonta Foundation | Sault Ste Marie | $1,466 |
| Sault Theatre Workshop | Sault Ste Marie | $26K |
| Saulteaux First Nation Employment & Training Inc. | Cochin | — |
| Saunders Memorial Trust | Toronto | — |
| Sauti Moja | Pembroke | $317K |
| Sauvé Foundation | Montreal | $1.6M |
| Sauve-Garde Nature | Venise-En-Quebec | $4,735 |
| Sauvetage A.G. Inc. | Saint-Colomban | — |
| Sauvetage de Montreal Hatzoloh/ Hatzoloh Rescue Squad of Montreal | Outremont | $135K |
| Sauvetage et recherche Aériens du Québec (SERABEC) Inc. | Quebec | — |
| Sauvetage médical | Ste-Sophie | $20K |
| Sauvetage Région 02 Inc | Chicoutimi | $187K |
| SAVAC - South Asian Visual Arts Centre | Toronto | $249K |
| Savage Foundation | Woodbridge | $82K |
| Savage Production Society | New Westminster | $733K |
| Savanna Agricultural Society | Silver Valley | $309K |
| Savanna Home and School Association | Silver Valley | — |
| Savanna Lighthouse Assembly | Silver Valley | $6,740 |
| Save A Child International Foundation | Port Coquitlam | $15K |
| Save a Child's Heart Foundation | Toronto | $1.7M |
| Save A Family Plan | London | $5.3M |
| Save a Leg Association | Toronto | — |
| Save African Child Uganda | Lasalle | $262K |
| Save Animals Through Rescue and Adoption (s.a.r.a.) | Surrey | $55K |
| Save Estuary Land Society | Parksville | $281 |
| Save Fanning School Inc. | Hampshire | $30K |
| Save Life Outreach Initiatives | Scarborough | $12K |
| Save Me Dog Rescue | Thornhill | $170K |
| Save My Child International Inc. | Unionville | — |
| Save Ontario Shipwrecks | Blenheim | $32K |
| Save Our Heritage Organization | Brighton | $68K |
| Save Our Scruff - Rehome & Rescue | Burlington | $601K |
| Save Our Seine River Environment Inc. | Winnipeg | $244K |
| Save Our Songbirds | Thunder Bay | $23K |
| Save-The-Cedar League | Vancouver | $124K |
| Save the Children Canada/aide À l'Enfance Canada | Toronto | $50.8M |
| Save the Jungle | Mississauga | — |
| Save the Mothers | Ancaster | $386K |
| Save the People International | Oakville | $24K |
| Save the Richmond Street Forest | Thorold | — |
| Save Your Skin Foundation | Penticton | $1.6M |
| SaveTheLasalle | Kirkland Lake | $251K |
| Saving Animals from Euthanasia Team Edmonton Society | Edmonton | $103K |
| Saving Grace Animal Society | Alix | $2M |
| Saving Station Foundation | Pointe-Claire | $99K |
| Saviour Lutheran Church | Delta | $136K |
| Saviour of the Nations Evangelical Lutheran Church | Vancouver | $386K |
| Savoir média | Montreal | $3.4M |
| Savoy Society of Ottawa | Ottawa | — |
| Savridi Singers Association | Calgary | $71K |
| Saw Video Association | Ottawa | $735K |
| Sawa World Association | Vancouver | $182K |
| Sawa World Foundation | Vancouver | — |
| Sawubona Project | Orleans | $215K |
| Sawyerville Baptist Church | Sawyerville | $115K |
| Sawyerville United Church | Saint-Isidore-De-Clifton | $41K |
| Saxon Foundation | Mississauga | $1.5M |
| Say Ça! Circle of Support for Refugee and Newcomer Students Say Ça! Cercle de Soutien aux Etudiants Refugies et NouveauxArrivants | Montreal | — |
| Say No For Nick | Ottawa | $0 |
| Sayal Charitable Foundation | Thornhill | — |
| Sayward Christian Fellowship Society | Sayward | $35K |
| Sayward Community Education Trust | Sayward | $3,639 |
| Sayward Community Health Society | Sayward | $60K |
| Sayyidah Zainab Muslim Community Centre | Ajax | $533K |
| Sayyiduna Uthman Islamic Academy | Georgetown | $524K |
| SB Centre for Security Governance | Waterloo | $1,561 |
| SBBS Charitable Society | Surrey | — |
| SBC Gallery of Contemporary Art | Montreal | $362K |
| Sca International | Newmarket | $122K |
| Scadding Court Community Centre Incorporated | Toronto | $3.1M |
| Scalabrini Charities for the Poor | Windsor | $3 |
| Scale Institute Society | Victoria | $11K |
| Scandia Church and Cemetery Board | Shell Lake | $697 |
| Scandia Community Centre | Scandia | $377K |
| Scandia Lutheran Church | Armena | $118K |
| Scandia Lutheran Church | Cabri | — |
| Scandia Lutheran Heritage Church Inc. | Wadena | $12K |
| Scandinavian Canadian Choir | Winnipeg | $2,775 |
| Scandinavian Centre Inc. | Winnipeg | $136K |
| Scaramella Concerts | Toronto | — |
| Scarboro Foreign Mission Society | Scarborough | $5.3M |
| Scarboro United Church | Calgary | $468K |
| Scarborough Arts | Scarborough | $811K |
| Scarborough Baptist Church | Scarborough | $72K |
| Scarborough Bluffs United Church | Scarborough | $316K |
| Scarborough Centre for Healthy Communities | Scarborough | $24.5M |
| Scarborough Chinese Alliance Church of the Christian and Missionary Alliance in Canada | Scarborough | $4.5M |
| Scarborough Chinese Baptist Church | Scarborough | $3.5M |
| Scarborough Chinese Bible Church | Scarborough | — |
| Scarborough Christian Fellowship Centre (scfc) | Scarborough | $5,040 |
| Scarborough Church of Christ | Scarborough | — |
| Scarborough Church of God | Scarborough | $336K |
| Scarborough Community Alliance Church of the Christian and Missionary Alliance in Canada | Toronto | $701K |
| Scarborough Creole Congregation of Jehovah's Witnesses Toronto Ontario | Scarborough | — |
| Scarborough Family Christian Church (SFCC) | Scarborough | $40K |
| Scarborough Food Security Initiative | Scarborough | $1.5M |
| Scarborough Full Gospel Assembly | Etobicoke | $355 |
| Scarborough Health Network | Scarborough | $967.9M |
| Scarborough Health Network Foundation | Scarborough | $35.5M |
| Scarborough Historical Society | Scarborough | $36K |
| Scarborough Iloko Congregation of Jehovah's Witnesses Scarborough Ontario | Scarborough | $9,901 |
| Scarborough Mandarin Alliance Church of the Christian & Missionary Alliance in Canada | Scarborough | $289K |
| Scarborough Mandarin Christian Church | Scarborough | $492K |
| Scarborough Music Theatre Inc. | Scarborough | $445K |
| Scarborough Muslim Association | Scarborough | $3.6M |
| Scarborough Philharmonic Orchestra | Scarborough | $326K |
| Scarborough Players | Scarborough | $185K |
| Scarborough Rotary Passport Club Charitable Fund | Mississauga | $150K |
| Scarborough Spoken Word Christian Fellowship | Whitby | $349K |
| Scarborough Tagalog Congregation of Jehovah's Witnesses Toronto Ontario | Scarborough | $17K |
| Scarborough Theatre Guild | Scarborough | $138K |
| Scarborough Women's Centre | Scarborough | $946K |
| Scaredy Cat Rescue | Corner Brook | $143K |
| Scat Street Cat Rescue Program Inc. | Saskatoon | $1M |
| Sccyber E-Learning Community | Calgary | $369K |
| Sce Lifeworks Inc. | Winnipeg | $6.5M |
| Scep Centre Society (regina) | Regina | $1M |
| Sceptiques du Québec Inc. | Montreal | $15K |
| Sceptre Memorial Gardens Association | Sceptre | $2,592 |
| Sceptre United Church | Sceptre | $34K |
| SCH' Eyk Housing Society | Vancouver | $3M |
| Schara Tzedeck Cemetery Board | New Westminster | $4.8M |
| Scharaf Family Charitable Trust | White Lake | $147K |
| Schein Foundation | Vancouver | $128K |
| Schell School Fundraising Committee | Holdfast | $2,716 |
| Schizophrenia Society of Alberta | Red Deer | $3.5M |
| Schizophrenia Society of Canada Foundation/fondation de Societe Canadienne de Schizophrenie | Steinbach | $217K |
| Schizophrenia Society of Canada/societe Canadienne de Schizophrenie | Concord | $1.1M |
| Schizophrenia Society of New Brunswick Inc/la Societe de Schizophrenie du Nouveau-Brunswick Inc | Miramichi | $235K |
| Schizophrenia Society of Newfoundland and Labrador Inc. | ST Johns | $68K |
| Schizophrenia Society of Prince Edward Island Inc | Stratford | — |
| Schizophrenia Society of Saskatchewan Inc. | Regina | $738K |
| Schlegel-Uw Research Institute for Aging Foundation | Waterloo | $50.6M |
| Schlegel Villages Benevolent Fund | Kitchener | $265K |
| Schlegel Villages Charitable Foundation | Kitchener | $12K |
| Schmelke Family Charitable Foundation | Vancouver | $137K |
| Schmidt Family Foundation | Abbotsford | $140K |
| Schoenfelder Mennonite Church Inc. | ST Francis Xavier | $127K |
| Schofam Charitable Foundation | Toronto | $549K |
| Scholar's Study Foundation | Vancouver | — |
| Scholarship Bursary & Education Committee Medical Alumni Association of University of Toronto | Toronto | $348K |
| Scholarship/Bursary for Indigenous Students in the Neuland Settlement Region of the Chaco of Paraguay (SBISNSRCP) | Waterloo | $251K |
| Scholarship Foundation of the Pacific | Little Fort | $139K |
| Scholarship Fund | Truro | $34K |
| Scholarship Fund of the Canadian Fire Safety Association-Association Canadienne de Securite Incendie | Markham | $15K |
| Scholarship Trust Fund of Hour a Day Study Club | Windsor | — |
| Scholarship Trust Fund of the Canadian Federation of University Women Belleville & District | Belleville | $35K |
| Scholarship Trust Fund under the will of Marial Laura Morse Mosher | Halifax | $525K |
| Scholmark Foundation | Toronto | — |
| Schomberg Agricultural Society | Schomberg | $153K |
| Schomberg Pastoral Charge | Schomberg | $89K |
| Schomberg Presbyterian Church | Schomberg | $66K |
| School After School Society | Summerland | — |
| School Congregation of Thunder Bay Ontario Canada | Thunder Bay | $11K |
| 'school Days' Museum Incorporated | Fredericton | $17K |
| School District No. 12 Scholarship Trust Committee | Woodstock | $61K |
| School District No 19 (revelstoke) Bursary Scholarship and Teaching AIDS Trust Fund | Revelstoke | $935 |
| School District No. 40 (New Westminster) | New Westminster | $110.2M |
| School District No. 83 (Kwsaltktnéws ne Secwepemcul'ecw) | Salmon Arm | $108.9M |