| University of Ottawa Heart Institute/l'institut de Cardiologie de l'Universite d'Ottawa | Ottawa | $298.7M |
| University of Ottawa Institute of Mental Health Research/ Institut de Recherche en Santé Mentale de l'Université d'Ottawa | Ottawa | $7M |
| University of Prince Edward Island | Charlottetown | $210.2M |
| University of Regina | Regina | $376.2M |
| University of Saskatchewan | Saskatoon | $1.3B |
| University of Saskatchewan (employees Charitable Donations Plan) | Saskatoon | $220K |
| University of Tartu Fund | York | $65K |
| University of the Fraser Valley | Abbotsford | $190.2M |
| University of the Fraser Valley Foundation | Abbotsford | $0 |
| University of Toronto Community Radio Inc. | Toronto | $686K |
| University of Toronto Schools | Toronto | $29.3M |
| University of Vancouver | Squamish | $734K |
| University of Victoria | Victoria | $847.1M |
| University of Victoria Foundation | Victoria | $33.6M |
| University of Waterloo | Waterloo | $1.4B |
| University of Windsor | Windsor | $464.1M |
| University of Windsor Employees Charity Trust | Windsor | $74K |
| University of Winnipeg Community Renewal Corporation | Winnipeg | $1.4M |
| University Presbyterian Church | Downsview | $137K |
| University Settlement | Toronto | $5.8M |
| University Women's Club of North York Scholarship Fund | North York | $11K |
| University Women's Club of Oakville Scholarship Fund | Oakville | $51K |
| University Women's Club of South Delta B.C. Education Fund | Delta | $12K |
| University Womens Club of Vancouver Trust Fund for Education | Vancouver | $52K |
| University Womens Club of Winnipeg Scholarship Fund | Winnipeg | $31K |
| University Women's Club St. Thomas Community Engagement Fund | Union | $614 |
| Univert Laval | Québec | — |
| Univillage Preschool and Infant Centre Inc. | Winnipeg | $1.3M |
| Univox Choirs Toronto Inc. | North York | $59K |
| UniWater Education Limited | Calgary | $200 |
| Unlimited Potential Community Services Society | Edmonton | $25.8M |
| Unlock Democracy | Markdale | $45K |
| Unlocking Potential Foundation | Calgary | $691K |
| Unmasking the Reality of Lung Cancer Society | Calgary | — |
| Unshakable Kingdom Believers | Guelph | $34K |
| Unsinkable Ltd. | Toronto | $876K |
| Until the Last Child | Toronto | $6,160 |
| Until We Meet Again - A Caring Network | Etobicoke | $36K |
| Untitled Art Society (Calgary) | Calgary | $379K |
| Untitled Church | Vancouver | $1.2M |
| Untold Giving Foundation | West Vancouver | $3.3M |
| Unveiling Life International | Woodbridge | — |
| Unwrap Theatre | Kitchener | $86K |
| Up and Running Guelph | Guelph | $114K |
| Up in the Air Theatre Society | Vancouver | $428K |
| Up With Women | Toronto | $2M |
| UPA Développement International | Longueuil | $9.9M |
| UpHere Worship Church | North York | $82K |
| UpHill Church | North York | $264K |
| Upland Birds Society | Vancouver | — |
| Uplands Baptist Church | Terrace | $80K |
| Uplands Baptist Church Inc. | Moncton | $172K |
| Uplands Centre Culturel et du Patrimoine | Sherbrooke | $428K |
| Uplands Charitable Foundation | Holland Landing | $1.2M |
| Uplifting Youth Foundation | North York | $8,792 |
| Uplook Ministries (canada) | Waterloo | $52K |
| Upper Blackville United Baptist Church | Arbeau Settlement | $60K |
| Upper Blue Rocks Cemetery Society | Blue Rocks | $7,700 |
| Upper Brighton Free Will Baptist Church Inc. | Somerville | — |
| Upper Canada Choristers Inc. | North York | $68K |
| Upper Canada College | Toronto | $80.5M |
| Upper Canada District School Board | Brockville | $479.9M |
| Upper Canada District School Board Champions for Kids Foundation | Brockville | $173K |
| Upper Canada Leger Centre for Education and Training | Brockville | $3.9M |
| Upper Canada Lodge B'Nai B'Rith Senior Citizens Foundation | Toronto | $1.8M |
| Upper Canada Playhouse | Morrisburg | $1.2M |
| Upper Credit Humane Society | Erin | $483K |
| Upper Falls Baptist Church | Vermilion Bay | $28K |
| Upper Fraser Valley Developmental Pre-School Society | Langley | — |
| Upper Fraser Valley Habitat for Humanity Society | Abbotsford | — |
| Upper Gagetown United Baptist Church | Upper Gagetown | $42K |
| Upper Grand Learning Foundation | Guelph | $939K |
| Upper Hainesville Cemetery | Upper Hainesville | $1,604 |
| Upper Hainesville Springs of Living Water Church | Zealand | $14K |
| Upper Hampstead Cemetery Limited | Upper Hampstead | $1,210 |
| Upper Island Women of Native Ancestry Society | Courtenay | — |
| Upper Kent United Pentecostal Church | Florenceville-Bristol | $181K |
| Upper Kingsclear Baptist Church Inc. | Upper Kingsclear | $164K |
| Upper Knoxford United Baptist Church | Upper Knoxford | $13K |
| Upper Londonderry Pastoral Charge United Church of Canada | Debert | $49K |
| Upper Lonsdale Preschool (council of Parent Participation Preschools in British Columbia | North Vancouver | $123K |
| Upper Mills United Church of Canada | Upper Mills | $24K |
| Upper Miramichi Community School Library | New Brandon Northumb CO | $45K |
| Upper Miramichi Volunteer Firefighters Association 'umvfa' | Boiestown | $8,406 |
| Upper Musquodoboit Fellowship Club | Halifax County | $5,588 |
| Upper Musquodoboit Playground Society | Newcomb Corner | $4,681 |
| Upper Nashwaak Agrena Association Inc. | Stanley | — |
| Upper Nashwaak Community Outreach Inc. | Stanley | $1.9M |
| Upper Northfield Community Hall Association | Upper Northfield | $2,960 |
| Upper Ottawa Valley Genealogical Group Inc. | Pembroke | — |
| Upper Paradise Academy | Hamilton | $54K |
| Upper Pine Gospel Chapel | Rose Prairie | $194K |
| Upper River Denys Cemetery Limited | River Denys | $2,680 |
| Upper Room Christian Ministries International | Markham | — |
| Upper Room Family Worship Center | Brampton | — |
| Upper Room Food Bank Association | Kingston | $129K |
| Upper Room Intercessory Ministry | Etobicoke | $22K |
| Upper Room Ministries | Toronto | $71K |
| Upper Room Ministries Church Edmonton | Edmonton | — |
| Upper Room Outreach Ministry | Barrie | $4,790 |
| Upper Room Pentecostal Tabernacle | Windsor | $30K |
| Upper Sackville-Anderson Settlement Pastoral Charge | Anderson Settlement | $14K |
| Upper Saint John River Valley Christmas Relief Fund Inc. | Centreville | $19K |
| Upper Skeena Hospice Society | Hazelton | — |
| Upper Stewiacke-Springside Pastoral Charge | Kemptown | $21K |
| Upper Thames Missionary Church | Mitchell | $385K |
| Upper Thames River Conservation Authority | London | $23.6M |
| Upper Vaughan Baptist Church | Upper Vaughan | — |
| Upper Woodstock Cemetery Company Inc. | Upper Woodstock | $2,655 |
| Upper Yonge Village Day CARE Centre | Toronto | $1.2M |
| Ups & Downs - Calgary Down Syndrome Parent Support Group Association | Calgary | $157K |
| Upsala Volunteer Ambulance Services Association | Upsala | $58K |
| Upsala Volunteer Firefighters Association | Upsala | $131K |
| Upsalquitch Pastoral Charge | Upsalquitch | $12K |
| Upskill Niagara | Welland | $264K |
| Upstanders Canada Antiracism Society | Delta | $30K |
| Upstream Music Association | Halifax | $172K |
| Upstream Ottawa Mental Health Community Support | Nepean | $1.1M |
| Upton Farm Trust Inc | Charlottetown | $4,535 |
| Upton Gospel Chapel | ST. Peters | $51K |
| Uptown Chabad | Thornhill | $1.7M |
| Uptown Church | White Rock | $92K |
| Uptown CYP | North York | $971K |
| Uptown Day CARE Inc. | The Pas | $836K |
| UpTown Waterloo Jazz Festival Inc. | Waterloo | $142K |
| Upward Missions | Terrebonne | — |
| Uquutaq Society | Iqaluit | $3.8M |
| UR Amazing Ministries | Lethbridge | $34K |
| Uranium Medical Research Centre | Markham | — |
| Urban Abbey | Thunder Bay | $686K |
| Urban Academy | New Westminster | $9.5M |
| Urban Alliance on Race Relations | Scarborough | $535K |
| Urban Christian Outreach (ottawa) | Ottawa | — |
| Urban Circle Training Centre Inc. | Winnipeg | $1.6M |
| Urban Farm Museum Society | Halifax | $18K |
| Urban Grace Church of Calgary | Calgary | $419K |
| Urban Horse Project Society | Vancouver | $336K |
| Urban Ink Production Society | Vancouver | $672K |
| Urban Manor Housing Society | Edmonton | $2.5M |
| Urban Missionaries' Association of Canada | Edmonton | $917 |
| Urban Native Youth Association | Vancouver | $19.3M |
| Urban Pardes / Paradis Urbain | Montreal | $508K |
| Urban Rural Mission Global Partners Foundation | Vancouver | $0 |
| Urban/Rural Rides-Transport Urbain/Rural Inc. | Salisbury | $1.3M |
| Urban Safari Rescue Society | Surrey | $274K |
| Urban Shaman Inc. | Winnipeg | $503K |
| Urban Society for Aboriginal Youth | Calgary | $3.6M |
| Urban Spirit Foundation | West Vancouver | $160K |
| Urban squash Toronto | North York | $956K |
| Urban Systems Foundation | Kamloops | $487K |
| Urban Tails Animal Support Network | Orangeville | $54K |
| Urban Village Church | Burnaby | $74K |
| Urban Wildlife Care | Grimsby | — |
| Urbanarts Community Arts Council | Toronto | $709K |
| UrbaNature Education | Montreal | $39K |
| Urbanpromise Ministries | Vancouver | $1.1M |
| Urbanpromise Toronto | North York | $1.2M |
| UrbanRoad Church | Abbotsford | — |
| Urgence-Vie | Drummondville | — |
| Urgency Room Seniors Clinic | North York | — |
| Urja | Coquitlam | $18K |
| Urology Interest Group Association | Edmonton | $24K |
| Ursuline Religious of the Diocese of London in Ontario | Chatham | $5.9M |
| Ursuline Sisters of Tildonk Inc. | Winnipeg | — |
| Uryadi's Village Canada | Calgary | $79K |
| USANA True Health Canada Foundation | Salt Lake City | $144K |
| USCAP Canada Foundation | Burnaby | — |
| Usher 1F Collaborative Canada | Kanata | $40K |
| Usher Syndrome Warriors Foundation | Washago | $56K |
| Usine C | Montreal | $3.2M |
| Utica Cemetery Board | Port Perry | $17K |
| Utopie Créatrice | Montreal | $274K |
| Uts Foundation | Toronto | $8.1M |
| UTSS Charities International | Surrey | $85K |
| Utter Vision Charity | North York | — |
| Utterson United Church | Utterson | $35K |
| Uttoxeter Cemetery | Prince George | — |
| uTurn Project Inc. | Calgary | $79K |
| Uuttuvak Foundation | Orleans | $3,110 |
| Uvillage Church | Vancouver | $108K |
| Uwc National Committee of Canada | Victoria | $36K |
| UWC (Toronto) Foundation | Toronto | $98K |
| Uxbridge Baptist Church | Uxbridge | $913K |
| Uxbridge Celebration of the Arts Inc. | Uxbridge | $2,435 |
| Uxbridge Chamber Choir | Uxbridge | $9,633 |
| Uxbridge Free Methodist Church | Uxbridge | $80K |
| Uxbridge Hospital Foundation | Uxbridge | $3.9M |
| Uxbridge Music Scholarship Trust | Uxbridge | $240 |
| Uxbridge Pastoral Charge | Uxbridge | $330K |
| Uxbridge Scott Historical Society | Uxbridge | $152K |
| Uxbridge Scugog Pet Food Bank Ltd. | Leaskdale | $121K |
| Uxbridge Youth Centre Inc. | Uxbridge | $124K |
| Uyghur Mosque | Mississauga | $8,163 |
| Uzazi Foundation | Nestleton Station | $9,015 |
| Uzima Women Relief Group International | Scarborough | $1.7M |
| Uzume Taiko Drum Group Society | Richmond | — |