| The Sidney Greenberg Family Foundation | Montreal | $4,584 |
| The Siebens-Drake Medical Research Institute | London | $1.4M |
| The Sigma XI Fund of Canada | Brossard | $3,118 |
| The Sign of Hope Society Archdiocese of Edmonton | Edmonton | $3.6M |
| The Sikh Initiative | Brampton | $74K |
| The Sikh Society of Thompson Inc | Thompson | $65K |
| The Siludette O'Connor Memorial Foundation | Edmonton | — |
| The Silver Creek Agricultural Society | New Norway | $184K |
| The Silver & Gold Pioneer Club of Wembley | Wembley | $19K |
| The Silver Hotel Group Ruparell Foundation | Mississauga | $533K |
| The Silver Social Club | Stockholm | $8,928 |
| The Silvio Bot Charitable Foundation | Oakville | $694 |
| The Simcha Congregation | Toronto | $11K |
| The Simcoe Caring Cupboard | Simcoe | $204K |
| The Simcoe Free Church | Thornton | $107K |
| The Simon and Maral Hasserjian Foundation | Thornhill | $57K |
| The Simon Minz Family Foundation | Scarborough | — |
| The Simon Poultney Foundation | Stony Plain | — |
| The Simons Foundation Canada | Vancouver | $931K |
| The Simpson Charitable Foundation | Niagara-ON-The-Lake | $216K |
| The Sims Foundation | Nanaimo | $4,636 |
| The Singh Foundation | Vancouver | $218K |
| The Singh & Kaur Seva Foundation | Brampton | — |
| The Singhal Family Foundation | Ottawa | — |
| The Sinneave Family Foundation | Calgary | $23.1M |
| The Sir Andrew Macphail (of Orwell P E I ) Foundation Inc | Vernon Bridge | $96K |
| The Sir Christopher Ondaatje Theatre Foundation | Chester | $42K |
| The Sir Edmund Hillary Foundation | Etobicoke | $164K |
| The Sir Ernest Macmillan Memorial Foundation | Ottawa | $17K |
| The Sir James Dunn Centennial Trust Inc | Rothesay | $303K |
| The Sir James Dunn Foundation Inc. | Rothesay | $4.1M |
| The Sir Mortimer B. Davis Jewish General Hospital Foundation | Montreal | $74.3M |
| The Sir Sandford Fleming College of Applied Arts and Technology | Peterborough | $307.3M |
| The Sir Thomas Roddick Hospital Foundation Inc | Stephenville | $70K |
| The Sir Winston Churchill Society of Calgary | Calgary | $124K |
| The Siro Martinello Memorial Bursary Fund Inc | Windsor | $5,979 |
| The Sisterhood of Saint John the Divine | Toronto | $4.4M |
| The Sisters Faithful Companions of Jesus | Calgary | — |
| The Sisters Faithful Companions of Jesus | Toronto | — |
| The Sisters of Charity of Providence in British Columbia | Edmonton | — |
| The Sisters of Charity of Providence of Western Canada | Edmonton | — |
| The Sisters of Instruction of the Child Jesus | Coquitlam | — |
| The Sisters of Our Lady Immaculate of the Diocese of Hamilton | Glen Morris | $631K |
| The Sisters of Our Lady of the Cross Provident Fund Society | Saskatoon | — |
| The Sisters of Saint Ann | Victoria | $2.1M |
| The Sisters of Saint Kosmas Aitolos Greek Orthodox Monastery | Bolton | $2.4M |
| The Sisters of Social Service | Toronto | $1.3M |
| The Sisters of St. Joseph for the Diocese of Toronto in Upper Canada | Toronto | $21.9M |
| The Sisters of ST Joseph of Sault Ste Marie | North Bay | $8.2M |
| The Sisters of the Good Shepherd of Toronto | Etobicoke | $5.4M |
| The Sisters of the Presentation | Prince Albert | — |
| The Sitka Foundation | Vancouver | $21.7M |
| The SITN Foundation | Laval | $947K |
| The Sixty Three Foundation | Toronto | $82.3M |
| The SJ Foundation | Calgary | $1.2M |
| The SJ Hillside Cemetery Association | James River | $38K |
| The SJP Foundation | London | — |
| The SJS Legacy Foundation | Thornhill | $134K |
| The Sky Is My Limit | Proton Station | — |
| The Slaight Family Foundation | Toronto | $27.2M |
| The Slave Lake Native Friendship Centre Society | Slave Lake | $1M |
| The Slavic Branch of the Pentecostal Assemblies of Canada | Brantford | $150K |
| The Slocan Valley Seniors' Housing Society | Winlaw | $380K |
| The Slovanic Cemetery Company | Mayerthorpe | $1,837 |
| The Slovenian-Canadian Scholarship Foundation Inc. | Hamilton | $576 |
| The Small Talk Society for Developmental Language Disorders in Pre-School Aged Children | Vancouver | — |
| The Small Wonders Charitable Organization | North York | $391K |
| The SMDL Charitable Foundation | Toronto | $357K |
| The Smile Company | Toronto | $752K |
| The Smile Mission Oral Health Outreach Society | Salmon Arm | $105 |
| The Smith and Vanstokkom Foundation | Calgary | $2.2M |
| The Smith Family Foundation | Antigonish | $18K |
| The Smith`s Cove Historical Society | Smiths Cove | $90K |
| The Smiths Falls Community Hospital Auxiliary | Smiths Falls | $107K |
| The Smoky Lake Agricultural Society | Smoky Lake | $814K |
| The Smoky Lake County Rural Crime Watch Association | Smoky Lake | $352 |
| The Smoky Lake Foundation | Smoky Lake | $5M |
| The Snowsuit Fund/Le fonds habineige | Ottawa | $2.8M |
| The Soberano Charitable Foundation | Thornhill | $66K |
| The Sobey Foundation | Stellarton | $8.5M |
| The Social Enrichment Mission | North York | — |
| The Social Network for Youth of Ottawa-Carleton | Ottawa | $50K |
| The Social Research and Demonstration Corporation | Ottawa | $13.6M |
| The Social Service Bureau of Sarnia | Sarnia | $6.6M |
| The Society for Development in Third World Countries | Edmonton | $6,197 |
| The Society for Korean and Related Studies | Markham | $3,591 |
| The Society for Near Eastern Studies | Montreal | — |
| The Society for Selections: a Career Support Service | Edmonton | $1.9M |
| The Society for Silent Witness Nova Scotia | Halifax | $14K |
| The Society for the Advancement of Young Scientists | Victoria | $34K |
| The Society for the District #1 Community Centre | Blandford | $111K |
| The Society for the Education of Children With Specific Learning Disabilities | North Vancouver | $9.8M |
| The Society for the Enhancement of Wild Salmon Stocks WSU | Margaree | $3,662 |
| The Society for the Preservation of Historic Thornhill | Thornhill | $18K |
| The Society for the Preservation of Vaudeville | Surrey | $11K |
| The Society for the Prevention of Cruelty to Animals (newfoundland and Labrador) | Saint John's | $2.3M |
| The Society for the Propagation of the Faith for Canada English Sector | Scarborough | $2.9M |
| The Society for the Study of Egyptian Antiquities | Toronto | $143K |
| The Society for Third World Dental Care (Dentistry for all) | Calgary | $205K |
| The Society Of Alberta Dance Theatre For Young People | Calgary | $124K |
| The Society of Beaux Esprits Playschool | Edmonton | — |
| The Society of Briar Hill Childrens Programs | Calgary | $1.9M |
| The Society of Christ Fathers in Canada | Scarborough | $383K |
| The Society of Friends of Nepal | Edmonton | $122K |
| The Society of Friends of the Medicine Hat Public Library | Medicine Hat | $7,808 |
| The Society of Friends of the Monarch Theatre | Medicine Hat | $112K |
| The Society of Friends of the Red Deer Public Library | Red Deer | $30K |
| The Society of High Prairie Regional Environmental Action Committee | Slave Lake | $72K |
| The Society of Housing Opportunities and Progressive Employment | Kelowna | $8.2M |
| The Society of Nanton First Baptist Fellowship | Nanton | $26K |
| The Society of ST Pius X (ontario) | Toronto | $2.2M |
| The Society of St. Vincent de Paul (Lakeshore Particular Council) | Bowmanville | $269K |
| The Society of ST. Vincent de Paul of Central Okanagan | Kelowna | $515K |
| The Society of ST Vincent de Paul - Particular Council of Brant | Brantford | $410K |
| The Society of ST. Vincent de Paul (peterborough) | Peterborough | $2.3M |
| The Society of ST. Vincent de Paul ST. Peter's Conference Ofgoderich | Goderich | $471K |
| The Society of ST. Vincent de Paul Vancouver Archidiocesan Central Council | Vancouver | $269K |
| The Society of the Friends of the Early Music Studio | Kelowna | $234 |
| The Society of the Friends of the Edmonton Public Library | Edmonton | $90K |
| The Society of the Salesians of Canada | Montreal | $1.6M |
| The Society of We are Canadians Too | Vancouver | $414K |
| the Society Saint-Vincent de Paul | Cornwall | $90K |
| The Society to End Homelessness in Burnaby | Burnaby | $189K |
| The Socrates Educational Foundation/la Fondation Educationnelle Socrate | Dollard des Ormeaux | $150K |
| The Sodality of ST. Edmund King and Martyr | Waterloo | $5,014 |
| The Sokol Manor Inc. | Brandon | $173K |
| The Solid Rock Church International Ministries of Edmonton | Edmonton | $99K |
| The Solid Rock Community Church | Surrey | $76K |
| The Solid Rock Fellowship | Chilliwack | $93K |
| The Solid Rock Foundation | Surrey | $1M |
| The Solomon Schechter Academy Children's Foundation la Fondation pour Enfants de L'Académie Solomon Schechter | Montreal | $2.6M |
| The Solon Foundation | Calgary | $20K |
| The Soltron Foundation | Montreal | — |
| The Song Shul | Toronto | $786K |
| The Sonor Foundation | Toronto | $31.8M |
| The Sonshine Family Foundation | Toronto | $1M |
| The Sonshine Lunch Club | Courtenay | $44K |
| The Sonshine Street Preschool | Langley | $950K |
| The Soo Line Historical Society Inc. | Weyburn | $99K |
| The Sooke Philharmonic Society | Sooke | $122K |
| The Sophia Hilton Foundation of Canada Inc. | Gore's Landing | $9,996 |
| The Soskin/SoFine Foundation | Vancouver | $60K |
| The Soul Care Resource Centre Inc. | Victoria Corner | $652 |
| The Sound Investment Community Choir | Meaford | $7,425 |
| The Soup Haven | Yorkton | $157K |
| The Soup Kitchen | Hay River | $72K |
| The Soup Van Foundation | Victoria | — |
| The Source Church Inc. | Winnipeg | $291K |
| The Source Club Society | Powell River | $126K |
| The Souris District Donor's Choice | Souris | $29K |
| The South Alberta Light Horse Regiment Foundation | Edmonton | $116K |
| The South Burnaby Gospel Hall Society | Burnaby | $66K |
| The South Country Christian Fellowship Baptist Church | Jaffray | $126K |
| The South-East Alberta Agricultural Society | Orion | $34K |
| The South Georgian Bay Community Health Centres | Wasaga Beach | $3.4M |
| The South Granville Cemetery Inc | Breadalbane | $7,869 |
| The South Hill Child CARE CO | Prince Albert | $758K |
| The South Saskatchewan Youth Orchestra Inc. | Regina | $46K |
| The South Shore Children's Chorus/la Chorale des Enfants de la Rive-Sud | Brossard | $12K |
| The South Shore Community Organization | Crapaud | $391K |
| The South Shore Genealogical Society | Lunenburg | $20K |
| The South Shore Hospice/Palliative Care Society | Bridgewater | $234K |
| The South Simcoe Theatre | Cookstown | $120K |
| The South Whiteshell Trail Association Inc. | Falcon Beach | $336K |
| The Southbeach Foundation | York | $245K |
| The Southdown Institute | Holland Landing | $4.6M |
| The Southeast Geri-Fitness Committee | Salisbury | — |
| The Southern Alberta Self-Help Association | Lethbridge | $1.7M |
| The Southern Francophone Education Region | Calgary | $65.6M |
| The Southern Kings and Queens Food Bank Inc | Lower Montague | $279K |
| The Southern Kings and Queens Home Health CARE Equipment Committee | Montague | $13K |
| The Southern Manitoba Choral Society | Altona | $14K |
| The Southwest Manitoba Regional Foundation Inc. | Deloraine | $177K |
| The Southwinds Foundation | Halifax | $71K |
| The Spark Foundation of Lloydminster | Lloydminster | $3.6M |
| The Spark of Hope Foundation | Toronto | $419K |
| The Sparwood Public Library Association | Sparwood | $302K |
| The Spatz Foundation | Halifax | $406K |
| The Speaker-Mabee Memorial Foundation | Fort Erie | $19K |
| The Spec Association for Children and Families | Brooks | $1.9M |
| The Special Needs Employment Service Inc | Sarnia | $988K |
| The Special Physical Equipment Committee for Seniors | Happy Valley - Goose Bay | $5,000 |
| The Spector Family Foundation | Montreal | $18K |
| The Speech and Stuttering Institute | North York | $1.2M |
| The Sperling Community Centre District | Sperling | $75K |
| The Spina Bifida & Hydrocephalus Association of British Columbia | Surrey | $81K |
| The Spinal Cerebrospinal Fluid (csf)leak of Canada | Ottawa | $95K |
| The Spinoza Foundation | Kelowna | $2,100 |
| The Spirit of Freedom Ministries | Maple Ridge | — |
| The Spirit of Trust | Montreal | $0 |
| The Spirit of Truth Church | North York | $87K |
| The Spirit River Settlement Historical Society | Spirit River | $40K |
| The Spiritual Assembly of Baha'is of Dorval | Dorval | — |
| The Spiritual Assembly of the Baha'is of Abbotsford | Abbotsford | $100K |
| The Spiritual Assembly of the Baha'is of Airdrie | Airdrie | $34K |
| The Spiritual Assembly of the Baha'is of Ajax | Ajax | $25K |
| The Spiritual Assembly of the Baha'is of Anmore | Anmore | $31K |
| The Spiritual Assembly of the Baha'is of Aurora Ont | Aurora | $60K |
| The Spiritual Assembly of the Baha'is of Baie d'Urfe | Baie d'Urfe | $14K |
| The Spiritual Assembly of the Baha'is of Barrie | Barrie | $8,556 |