| Emmanuel United Church | Peterborough | $558K |
| Emmanuel United Church United Church of Canada | Sault Ste. Marie | $174K |
| Emmanuel United Church | Waterloo | $452K |
| Emmanuel United Pentecostal Church | Winnipeg | $96K |
| Emmanuel's Wish Foundation | Barrie | $103K |
| Emmaus Anglican Church/Église Anglicane Emmaus | Montreal | $188K |
| Emmaus Anglican Church Sault Ste Marie | Sault Ste Marie | $162K |
| Emmaus Church | Mississauga | $170K |
| Emmaus Community | Victoria | $162K |
| Emmaus Formation Centre | Mississauga | $198K |
| Emmaus House | ST. John's | $111K |
| Emmaus Korean Methodist Church | North York | $56K |
| Emmaus Lutheran Church | Burnaby | $157K |
| Emmaus Lutheran Church Edmonton | Edmonton | $139K |
| Emmaus Lutheran Church Incorporated of Drayton Valley Alberta | Drayton Valley | $92K |
| Emmaus Lutheran Church | Sexsmith | $0 |
| Emmaus Place Society | Prince George | $398K |
| Emmaus Road Anglican Church | Langley | $133K |
| Emmaus Road Ministries | Hamilton | $170 |
| Emmpower Foundation | Toronto | — |
| Emo Christian Reformed Church | Emo | $257K |
| Emo-Devlin United Church Board | Emo | $248K |
| Emo & District Hospital Auxiliary | Emo | $12K |
| Emo Food Bank and Thrift Shop | Emo | $68K |
| Emo Meals on Wheels | Emo | $6,128 |
| Emo 'Ya M'mbondo du Canada | Calgary | $17K |
| Emotions Health and Wellness Society of British Columbia | Surrey | $171K |
| Empart Canada | Scarborough | $126K |
| Empatheia | Scarborough | $32K |
| Empathy for Peace L'Empathie pour la paix | Toronto | — |
| Empathy House of Recovery | Ottawa | $548K |
| Employ to Empower Foundation | Vancouver | $895K |
| Employabilities Society of Alberta | Edmonton | $6.8M |
| Employees' Charitable Fund | Edmonton | — |
| Employees' Community Contribution of Dillon Consulting Limited | London | — |
| Employment and Education Resource Centre of Cornwall and District Inc. | Cornwall | $3.9M |
| Employment Help Centre | Beamsville | $1.7M |
| Employment Planning and Counselling-Peterborough | Peterborough | $3M |
| Employment Solutions for Immigrants Inc. | Winnipeg | $3.9M |
| Empower Armenia Inc. | King | — |
| Empower Global Inc. | Oakville | $181K |
| Empower Ministries | Barrie | $14M |
| Empower Simcoe Foundation | Barrie | $875K |
| Empower Simcoe Services | Barrie | $56M |
| Empower The Disability Resource Centre Inc. | ST. John's | $1.1M |
| Empower Through Music Society | Vancouver | $23K |
| Empowered By Love Ministries | Rockland | — |
| Empowered Futures Inc. | Calgary | $2,865 |
| Empowered Kids Ontario / Enfants Avenir Ontario | Toronto | $4.4M |
| Empowered Life Church | Scarborough | $706K |
| Empowered Life Coaching Foundation | Nobleton | $34K |
| EmpowerEd Refugee Children | Gloucester | $28K |
| Empowered Support Services Society | Hope | $624K |
| Empowered To Win Ministries Canada | Brampton | $51K |
| Empowering Artists | Vancouver | — |
| Empowering Citizens for Health and Opportunity Society | Whitecourt | $1.9M |
| Empowering Dreams Society | Rocky View County | $183K |
| Empowering Indigenous Youth in Governance and Leadership (EIYGL) | Winnipeg | $9,176 |
| Empowering Kids in Uganda Society | Yellowknife | $31K |
| Empowering Moms and Children Organization(EMCO) | Richmond Hill | $65K |
| Empowerment Center Church (Edmonton) | Edmonton | $232K |
| Empowerment House of Worship | Scarborough | $131K |
| Empress & District Historical Society | Empress | $57K |
| Empress Friendship Centre | Empress | $38K |
| Empty Arms: Perinatal Loss Support Services Incorporated | Saskatoon | $269K |
| Empty Stocking Fund Inc. | North Battleford | $269K |
| Ems Cadets Alberta Council | ST. Albert | $14K |
| Emsdale Agricultural Society | Emsdale | — |
| Emsdale Pastoral Charge | Emsdale | $55K |
| Emsley Family Foundation Inc. | Regina | $50K |
| Emu School Age Centre Incorporated | Winnipeg | $536K |
| Emunah Canada | North York | $1.3M |
| En Coeur la Fondation Québécoise pour les Enfants Malades du Coeur | Montreal | $1.5M |
| En Marge 12-17 | Montreal | $1.9M |
| En son nom - Vie consacree aujourd'hui | Montréal | — |
| En Tout C.a.s. (concertation Aide Soutien) Jeunesse | Rimouski | $247K |
| Enaahtig Healing Lodge and Learning Centre | Victoria Harbour | $6.8M |
| Enable Haiti | Kingsville | $77K |
| Enablis Foundation Canada | Montreal | $9,000 |
| Enactus Canada | Toronto | $2.9M |
| Enaji Madinamage - MIDJM/The Sharing Place Food Bank | Golden Lake | $37K |
| Ena's Community Cats Society | Chilliwack | $87K |
| Enchant Charitable Trust | Lethbridge | $288 |
| Encompass Community Charitable Foundation | Wainwright | $266K |
| Encompass Community Safety Agency Society | Edmonton | $11.5M |
| Encompass Foundation | North Vancouver | — |
| Encompass Partnerships of The Christian and Missionary Alliance in Canada | Calgary | $325K |
| Encompass Support Services Society | Langley | $6.8M |
| Encore Ministries of Calgary | Calgary | $28K |
| Encore! Sistema Quebec | Beaconsfield | $161K |
| Encore Symphonic Concert Band | Scarborough | $29K |
| Encore the Concert Band | London | $30K |
| Encounter Church | Victoria | $242K |
| Encounter Church Amherstburg | Amherstburg | $433K |
| Encounter Church Assembly of God | Winnipeg | $86K |
| Encounter Church Kingston | Kingston | — |
| Encounter Church of Brooks | Brooks | $387K |
| Encounter Covenant Church | Mississauga | $311K |
| Encounter Ministries Canada | Jarvis | $48K |
| Encounter the Truth | Nepean | — |
| Encounter World Religions | Guelph | $242K |
| Encountering Hope Ministries Canada Inc. | Winnipeg | — |
| Encourage Empower Support and Protect (EESP) young families | Cambridge | — |
| End Homelessness Winnipeg Inc. | Winnipeg | $33.8M |
| End Malnutrition Foundation | Ottawa | $0 |
| End of Steel Heritage Society | Hines Creek | $27K |
| End of The Rainbow Foundation | Calgary | $277K |
| END Sexual Violence NL INC. | ST. John's | $697K |
| End Time Message Tabernacle Edmonton | Edmonton | $1.1M |
| End-Time Ministries Inc. | Chatham | $106K |
| End Time Remnants Church of God | London | $30K |
| End Time Victory Outreach Inc. | Renfrew | — |
| End-Time World Revival Ministry | Brampton | — |
| Endangered Ecosystems Alliance | Vancouver | $382K |
| Endangered Species Fund of Canada | Orono | $12K |
| Endeavour Fellowship Chapel | Endeavour | $44K |
| Endeavour Volunteer Consulting for Non-Profits | Toronto | $8,566 |
| Enderby and District Arts Council Society | Enderby | $96K |
| Enderby and District Museum Society | Enderby | $62K |
| Enderby Congregation of Jehovah's Witnesses Enderby British Columbia | Enderby | $39K |
| Enderby & District Community Resource Centre Society | Enderby | $172K |
| Enderby & District Senior Citizens Complex | Enderby | $107K |
| Enderby Evangelical Chapel | Enderby | $318K |
| Enderby Pastoral Charge | Enderby | $62K |
| Enderby Preschool Society | Enderby | $830K |
| Ending Violence Association of British Columbia | Vancouver | $3.7M |
| Endla & John Gilmour Foundation | Toronto | $353K |
| Endless Possibilities & Hope Development Organization | Scarborough | — |
| Endometriosis Association (canada) Incorporated | London | — |
| Endometriosis Events | Etobicoke | $5,483 |
| Endowment Society of the Calgary Registered Music Teachers | Calgary | $18K |
| Ends of the Earth Courier for Christ Inc. | Alix | $125K |
| Endswell 2021 Foundation | Vancouver | $1.6M |
| Endswell Foundation | Vancouver | — |
| Endtime Harvest for Christ International Ministries | Scarborough | $141K |
| Endtime Harvest Outreach Prayer Ministries | North York | — |
| Enduring Heart Ministries | Oxford Mills | $6,335 |
| Enduring Word | North Vancouver | — |
| Energy for Opportunity | Windsor | — |
| Energy Safety Canada | Calgary | $34.5M |
| Energyminute Education Foundation | Calgary | $0 |
| Enfance Libre Lanaudière | Joliette | $416K |
| Enfance Lyme Québec | Laval | — |
| Enfant Mode d'Emploi | Sainte-Therese | $79K |
| Enfantaisie Haute-Gaspésie | Sainte-Anne-Des-Monts | $462K |
| Enfants de Bolivie | Pointe aux Trembles | $156K |
| Enfants de San Andres-Lima | Longueuil | $9,539 |
| Enfants d'Orient et d'Occident Adoption et parrainage du Québec | Montreal | $244K |
| Enfants Tiers-Monde (5 5 5) | Trois-Rivieres | $235K |
| Enfants transgenres Canada/ Gender Creative Kids Canada | Montreal | $231K |
| Engage and Change | Toronto | $301K |
| Engage Network Church of Spruce Grove | Spruce Grove | $411K |
| Engage Nova Scotia Civic Engagement Society | Halifax | $952K |
| Engage Today | Winnipeg | $803K |
| Engaging Community and Arts Inc. | ST. John's | $12K |
| Engedi Spiritual Formation | Markham | $126K |
| Engelite Charitable Foundation | Toronto | — |
| Engelking Foundation | Edmonton | — |
| Engineering and Geoscience Education Foundation Inc. | Winnipeg | $28K |
| Engineering Little Miracles Foundation | Foothills | $109 |
| Engineering Ministries International Canada | Calgary | $1.3M |
| Engineers and Geoscientists BC Benevolent Fund Society | Burnaby | — |
| Engineers and Geoscientists BC Foundation | Burnaby | $358K |
| Engineers of Tomorrow | Orangeville | $324K |
| Engineers Without Borders (canada) Organization/ingenieurs Sans Frontieres (canada) Organization | Toronto | $1.7M |
| Englee Pastoral Charge | Sandy Cove | $79K |
| Englefeld Good Neighbors Club | Englefeld | $7,219 |
| Englefeld Union Cemetery Association | Englefield | — |
| Englehart and Area Child CARE Centre | Englehart | $557K |
| Englehart and District Hospital Inc. | Kirkland Lake | — |
| Englehart & Area Food Bank | Englehart | $142K |
| Englehart Baptist Church | Englehart | $37K |
| Englehart & District Wheelchair Bus Fundraising | Englehart | $4,339 |
| English at First | Waterloo | $893K |
| English Bay Congregation of Jehovah's Witnesses Vancouver British columbia | Vancouver | $27K |
| English Bulldog Rescue of Ontario | Otonabee | $104K |
| English Evangelical Lutheran Church of the Redeemer | Vancouver | $241K |
| English Harbour Arts Association LTD. | ST. John's | $36K |
| English Language Institute in China Society | Langley | $1.7M |
| English Language Tutoring for the Ottawa Community | Ottawa | $637K |
| English-Montreal School Board/Commission Scolaire English-Montreal | Montreal | $435.3M |
| English-Speaking Catholic Council Inc./conseil Catholique de l'Expression Anglaise Inc. | Montreal | $182K |
| Englishtown Auxiliary Fire Department | Englishtown | $21K |
| Enjeu et Environnement Jeunesse Inc. | Montreal | $691K |
| Enjoy Life Church International Edmonton | Edmonton | $646K |
| Enku Scholarship Fund | Scarborough | $1,290 |
| Enliven Cancer Care | Huntsville | $84K |
| Enliven Christian Fellowship Edmonton | Edmonton | $74K |
| Enneagram Prison Project Canada | Vancouver | $60K |
| Ennerdale Road Baptist Church Inc. | Toronto | $207K |
| Enniskillen-Tyrone Pastoral Charge | Bowmanville | $215K |
| Ennotville Historical Library | Elora | — |
| Enoch Society for Care of the Aging | Toronto | $26K |
| Enrich Life Church Inc. | Regina | $83K |
| Enrichment Centre for Mental Health | Belleville | $1.2M |
| Ens Family Foundation Inc. | Saskatoon | — |
| Ensemble anonymus | Québec | $143K |
| Ensemble Antoine-Perreualt | Rimouski | $27K |
| Ensemble Arion | Outremont | $965K |
| Ensemble ArtChoral Inc | Montreal | $932K |